Optimal control of a multi-scale HIV-opioid model (Q6571838)

The paper studies optimal control of a multi-scale HIV-opioid model. It introduces an optimal control theory of multi-scale models of two interacting epidemics. Two control measures are considered at the population scale including treating the opioid addiction and reducing the HIV risk among opioid users. Two within-host scale control measures are used, namely, antiviral therapy blocking HIV entry to the target cells and antiviral therapy preventing the infected target cells from producing new HIV particles. The existence and uniqueness of the optimal control are established. Some numerical simulations are conducted to illustrate the theoretical results.