Mathematical modelling of T-cell proliferation
The authors study a number of models of the T-lymphocyte proliferation process, both in vivo and in vitro. The models consist of large systems of nonlinear ordinary and delay differential equations which take into account cell-cycle progression and regulation by lymphocines. Using numerical solutions of the differential equations and real, experimental data, the authors are able to carry out a program of parameter estimation. They are also able to experiment with the results of varying certain parameters. They show the possibility of immunocorrection (by means of an injection of a pharmacologic dose of IL-2) during the immune response to viral hepatitis B with T-lymphocyte deficiency.
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