Immune response model fitting to CD4^+ T cell data in \textit{lymphocytic choriomeningitis virus} LCMV infection

DOI10.1007/978-3-030-78163-7_1MaRDI QIDQ2089447zbMATH OpenOpenAlexFDO

Authors Atefeh Afsar, Filipe Martins, B. Oliveira, Alberto Pinto

Publication date 22 October 2022

Full work available at URL https://doi.org/10.1007/978-3-030-78163-7_1

zbMATH Keywords

residualsT cellsantigenic stimulationfitsepitope gp61epitope NP309regulatory T cells (Tregs)\textit{lymphocytic choriomeningitis virus} (LCMV)

Mathematics Subject Classification ID

Qualitative investigation and simulation of ordinary differential equation models (34C60) Pathology, pathophysiology (92C32)

Recommendations

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Cites work

• A fit of CD4^+ T cell immune response to an infection by lymphocytic choriomeningitis virus
• A transcritical bifurcation in an immune response model
• Autoimmunity arising from bystander proliferation of T cells in an immune response model
• Dynamics and biological thresholds
• Immune response dynamics
• Modelling the suppression of autoimmunity after pathogen infection
• Regulatory T cell adjustment of quorum growth thresholds and the control of local immune responses
• Sensibility of the quorum growth thresholds controlling local immune responses
• The role of tunable activation thresholds in the dynamics of autoimmunity
• Tolerance and immunity in a mathematical model of T-cell mediated suppression

Cited in

(2)

• A fit of CD4^+ T cell immune response to an infection by lymphocytic choriomeningitis virus
• Modelling the dynamics of LCMV infection in mice. II: Compartmental structure and immunopathology

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