Predicting pathogen-specific CD8 T cell immune responses from a modeling approach

DOI10.1016/J.JTBI.2015.03.033MaRDI QIDQ2630311zbMATH OpenOpenAlexWikidataFDO

Authors Yanyan Li

Publication date 27 July 2016

Published in Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1016/j.jtbi.2015.03.033

zbMATH Keywords

CD8 T cellsimmune responsenonlinear modelparameter value estimationpredictive model

Mathematics Subject Classification ID

Medical epidemiology (92C60)

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Cites work

• A simple cellular automaton model for influenza A viral infections
• Estimating division and death rates from CFSE data
• Estimating lymphocyte division and death rates from CFSE data
• Generals die in friendly fire, or modeling immune response to HIV
• Mathematical model of the primary CD8 T cell immune response: stability analysis of a nonlinear age-structured system
• Modeling amantadine treatment of influenza A virus in vitro
• Modeling regulation mechanisms in the immune system
• Modeling the interaction of cytotoxic T lymphocytes and influenza virus infected epithelial cells
• Models of CD8+ responses: 1. what is the antigen-independent proliferation program
• Probing the effects of the well-mixed assumption on viral infection dynamics
• Quantifying T lymphocyte turnover
• Simple scaling laws for influenza A rise time, duration, and severity

Cited in

(15)

• Physiological factors leading to a successful vaccination: a computational approach
• A multiscale model of the CD8 T cell immune response structured by intracellular content
• Dependence of CD8 T cell response upon antigen load during primary infection.
• A fit of CD4^+ T cell immune response to an infection by lymphocytic choriomeningitis virus
• Immune response model fitting to \(\mathrm{CD4^+}\) \(\mathrm{T}\) cell data in \textit{lymphocytic choriomeningitis virus} LCMV infection
• Mathematical modeling to guide experimental design: T cell clustering as a case study
• Models of CD8+ responses: 1. what is the antigen-independent proliferation program
• Modeling the effect of memory in the adaptive immune response
• Mathematically modeling dynamics of T cell responses: predictions concerning the generation of memory cells
• A minimal model of T cell avidity may identify subtherapeutic vaccine schedules
• A statistical analysis of memory CD8 T cell differentiation: An application of a hierarchical state space model to a short time course microarray experiment
• Mathematical model of the primary CD8 T cell immune response: stability analysis of a nonlinear age-structured system
• A fractional diffusion model of CD\(8^+\) T cells response to parasitic infection in the brain
• Mathematical models for immunology: current state of the art and future research directions
• Modeling the CD8+ T cell immune response to influenza infection in adult and aged mice

Describes a project that uses

Uses Software

• DEDiscover
• PottersWheel

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