A minimal model of T cell avidity may identify subtherapeutic vaccine schedules

DOI10.1101/2020.12.06.413864MaRDI QIDQ2240254zbMATH OpenOpenAlexFDO

Authors Adarsh Kumbhari, Danya Rose, Peter P. Lee, Peter S. Kim

Publication date 8 November 2021

Published in Mathematical Biosciences (Search for Journal in Brave)

Copyright license Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International

Full work available at URL https://doi.org/10.1101/2020.12.06.413864

zbMATH Keywords

immunotherapyminimal modelcancer vaccinesCTL avidity

Mathematics Subject Classification ID

Medical applications (general) (92C50) Medical epidemiology (92C60)

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Cites work

• A mathematical model of the enhancement of tumor vaccine efficacy by immunotherapy
• Alternative to Ritt's pseudodivision for finding the input-output equations of multi-output models
• An algorithm for finding globally identifiable parameter combinations of nonlinear ODE models using Gröbner bases
• Developing a minimally structured mathematical model of cancer treatment with oncolytic viruses and dendritic cell injections
• Finding identifiable parameter combinations in nonlinear ODE models and the rational reparameterization of their input-output equations
• Identification of parametric models from experimental data. Transl. from an upd. French version by the authors, with the help of John Norton
• Mathematical modelling of cancer stem cell-targeted immunotherapy
• On immunotherapies and cancer vaccination protocols: a mathematical modelling approach
• Optimisation of anti-cancer peptide vaccines to preferentially elicit high-avidity T cells
• Periodically pulsed immunotherapy in a mathematical model of tumor, CD4^+ T cells, and antitumor cytokine interactions
• Quantifying T lymphocyte turnover
• The union between structural and practical identifiability makes strength in reducing oncological model complexity: a case study

Cited in

(1)

• Optimisation of anti-cancer peptide vaccines to preferentially elicit high-avidity T cells

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