Modeling the CD8+ T cell immune response to influenza infection in adult and aged mice

DOI10.1016/J.JTBI.2024.111898MaRDI QIDQ6594288zbMATHFDO

Authors Benjamin Whipple, Tanya A. Miura, Esteban A. Hernandez-Vargas

Publication date 28 August 2024

Published in Journal of Theoretical Biology (Search for Journal in Brave)

zbMATH Keywords

influenzaagingmathematical modelCD8+ T cellsmurine model

Mathematics Subject Classification ID

Pathology, pathophysiology (92C32)

Recommendations

• Age-related changes to the immune system exacerbate the inflammatory response to pandemic H1N1 infection
• Modelling cross-reactivity and memory in the cellular adaptive immune response to influenza infection in the host
• Predicting pathogen-specific CD8 T cell immune responses from a modeling approach
• A target-cell limited model can reproduce influenza infection dynamics in hosts with differing immune responses
• Modeling T-cell repertoire response to a viral infection with short immunity

Cites work

• A dynamical model of human immune response to influenza A virus infection
• Differential Elimination for Dynamical Models via Projections with Applications to Structural Identifiability
• Gaussian processes for machine learning.
• Global sensitivity analysis: The primer
• Modeling the interaction of cytotoxic T lymphocytes and influenza virus infected epithelial cells
• On identifiability of nonlinear ODE models and applications in viral dynamics
• Scikit-learn: machine learning in Python
• The Elements of Statistical Learning

Cited in

(2)

• Modeling T-cell repertoire response to a viral infection with short immunity
• Ex vivo experiments shed light on the innate immune response from influenza virus

This page was built for publication: Modeling the CD8+ T cell immune response to influenza infection in adult and aged mice

Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q6594288)