Modelling cross-reactivity and memory in the cellular adaptive immune response to influenza infection in the host
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Publication:2013486
DOI10.1016/J.JTBI.2016.11.008zbMATH Open1368.92106arXiv1606.00495OpenAlexW2415323305WikidataQ40447652 ScholiaQ40447652MaRDI QIDQ2013486FDOQ2013486
Jane M. Heffernan, Ada W. C. Yan, Pengxing Cao, Nicole L. La Gruta, Karen L. Laurie, Jodie McVernon, James M. McCaw, Kylie M. Quinn
Publication date: 8 August 2017
Published in: Journal of Theoretical Biology (Search for Journal in Brave)
Abstract: The cellular adaptive immune response plays a key role in resolving influenza infection. Experiments where individuals are successively infected with different strains within a short timeframe provide insight into the underlying viral dynamics and the role of a cross-reactive immune response in resolving an acute infection. We construct a mathematical model of within-host influenza viral dynamics including three possible factors which determine the strength of the cross-reactive cellular adaptive immune response: the initial naive T cell number, the avidity of the interaction between T cells and the epitopes presented by infected cells, and the epitope abundance per infected cell. Our model explains the experimentally observed shortening of a second infection when cross-reactivity is present, and shows that memory in the cellular adaptive immune response is necessary to protect against a second infection.
Full work available at URL: https://arxiv.org/abs/1606.00495
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Cites Work
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Cited In (8)
- A target-cell limited model can reproduce influenza infection dynamics in hosts with differing immune responses
- The role of long-lived plasma cells in viral clearance
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- Modeling the interaction of cytotoxic T lymphocytes and influenza virus infected epithelial cells
- An approximate solution of the interferon-dependent viral kinetics model of influenza
- The rate of viral transfer between upper and lower respiratory tracts determines RSV illness duration
- Impact of influenza vaccine-modified infectivity on attack rate, case fatality ratio and mortality
- Modelling immune memory development
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