Mathematical modelling of immune response in tissues
Summary: We have developed a spatial-temporal mathematical model (PDE) to capture fundamental aspects of the immune response to antigen. We have considered terms that broadly describe intercellular communication, cell movement, and effector function (activation or inhibition). The PDE model is robust to variation in antigen load and it can account for (1) antigen recognition, (2) an innate immune response, (3) an adaptive immune response, (4) the elimination of antigen and subsequent resolution of the immune response or (5) equilibrium of the immune response to the presence of persistent antigen (chronic infection) and the formation of a granuloma.
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- scientific article; zbMATH DE number 4202084 (Why is no real title available?)
- scientific article; zbMATH DE number 2160984 (Why is no real title available?)
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