miRNA-disease association prediction with collaborative matrix factorization
Summary: As one of the factors in the noncoding RNA family, microRNAs (miRNAs) are involved in the development and progression of various complex diseases. Experimental identification of miRNA-disease association is expensive and time-consuming. Therefore, it is necessary to design efficient algorithms to identify novel miRNA-disease association. In this paper, we develop the computational method of Collaborative Matrix Factorization for miRNA-Disease Association prediction (CMFMDA) to identify potential miRNA-disease associations by integrating miRNA functional similarity, disease semantic similarity, and experimentally verified miRNA-disease associations. Experiments verifiy that CMFMDA achieves intended purpose and application values with its short consuming-time and high prediction accuracy. In addition, we use CMFMDA on Esophageal Neoplasms and Kidney Neoplasms to reveal their potential related miRNAs. As a result, 84\% and 82\% of top 50 predicted miRNA-disease pairs for these two diseases are confirmed by experiment. Not only this, but also CMFMDA could be applied to new diseases and new miRNAs without any known associations, which overcome the defects of many previous computational methods.
- A novel neighborhood-based computational model for potential miRNA-disease association prediction
- A new computational method based on heterogeneous network for predicting microRNA-disease associations
- A novel approach for predicting disease-lncRNA associations based on the distance correlation set and information of the miRNAs
- Maximal entropy random walk on heterogenous network for miRNA-disease association prediction
- A novel model for predicting associations between diseases and lncRNA-miRNA pairs based on a newly constructed bipartite network
- A novel approach for predicting disease-lncRNA associations based on the distance correlation set and information of the miRNAs
- A novel method for predicting disease-associated lncRNA-mIRNA pairs based on the higher-order orthogonal iteration
- A novel neighborhood-based computational model for potential miRNA-disease association prediction
- Detecting composite functional module in miRNA regulation and mRNA interaction network
- A new computational method based on heterogeneous network for predicting microRNA-disease associations
- Identify potential circRNA-disease associations through a multi-objective evolutionary algorithm
- Maximal entropy random walk on heterogenous network for miRNA-disease association prediction
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