Modeling adhesion-independent cell migration

DOI10.1142/S021820252050013XMaRDI QIDQ4960349zbMATH OpenOpenAlexFDO

Authors Gaspard Jankowiak, Diane Peurichard, Anne Reversat, Michael Sixt, Christian Schmeiser

Publication date 15 April 2020

Published in M\(^3\)AS. Mathematical Models \& Methods in Applied Sciences (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1903.09426

zbMATH Keywords

variational methodsweak solutionsactin polymerizationcellular cortexcell motility modeling

Mathematics Subject Classification ID

Variational methods applied to PDEs (35A15) Second-order parabolic systems (35K40) Initial-boundary value problems for second-order parabolic systems (35K51) PDEs in connection with biology, chemistry and other natural sciences (35Q92) Cell movement (chemotaxis, etc.) (92C17)

Abstract: A two-dimensional mathematical model for cells migrating without adhesion capabilities is presented and analyzed. Cells are represented by their cortex, which is modelled as an elastic curve, subject to an internal pressure force. Net polymerization or depolymerization in the cortex is modelled via local addition or removal of material, driving a cortical flow. The model takes the form of a fully nonlinear degenerate parabolic system. An existence analysis is carried out by adapting ideas from the theory of gradient flows. Numerical simulations show that these simple rules can account for the behavior observed in experiments, suggesting a possible mechanical mechanism for adhesion-independent motility.

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Cites work

• Mathematics of cell motility: Have we got its number?
• Multiple Integrals in the Calculus of Variations and Nonlinear Elliptic Systems. (AM-105)
• ON A „MONOTONICITY” METHOD FOR THE SOLUTION OF NONLINEAR EQUATIONS IN BANACH SPACES

Cited in

(9)

• The mathematics of mechanobiology and cell signaling. Abstracts from the workshop held February 25--March 3, 2018
• Modeling of adhesion, protrusion, and contraction coordination for cell migration simulations
• Cell speed is independent of force in a mathematical model of amoeboidal cell motion with random switching terms
• The influence of nucleus mechanics in modelling adhesion-independent cell migration in structured and confined environments
• scientific article; zbMATH DE number 1120708 (Why is no real title available?)
• A model of cell motility leading to biphasic dependence of transport speed on adhesive strength
• A 3-D model used to explore how cell adhesion and stiffness affect cell sorting and movement in multicellular systems
• Cell migration with multiple pseudopodia: temporal and spatial sensing models
• A non local model for cell migration in response to mechanical stimuli

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