Nonparametric inference of doubly stochastic Poisson process data via the kernel method
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Abstract: Doubly stochastic Poisson processes, also known as the Cox processes, frequently occur in various scientific fields. In this article, motivated primarily by analyzing Cox process data in biophysics, we propose a nonparametric kernel-based inference method. We conduct a detailed study, including an asymptotic analysis, of the proposed method, and provide guidelines for its practical use, introducing a fast and stable regression method for bandwidth selection. We apply our method to real photon arrival data from recent single-molecule biophysical experiments, investigating proteins' conformational dynamics. Our result shows that conformational fluctuation is widely present in protein systems, and that the fluctuation covers a broad range of time scales, highlighting the dynamic and complex nature of proteins' structure.
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Cited in
(6)- Nonparametric inference of doubly stochastic Poisson process data via the kernel method
- A selective view of stochastic inference and modeling problems in nanoscale biophysics
- Estimating doubly stochastic Poisson process with affine intensities by Kalman filter
- Nonparametric intensity estimation from noisy observations of a Poisson process under unknown error distribution
- Statistical methodology in single-molecule experiments
- Nonparametric tests for Cox processes
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