Patient specific seizure prediction system using Hilbert spectrum and Bayesian networks classifiers

DOI10.1155/2014/572082MaRDI QIDQ2262544zbMATH OpenOpenAlexDBLPWikidataFDO

Authors Yanyan Li

Publication date 16 March 2015

Published in Computational \& Mathematical Methods in Medicine (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1155/2014/572082

Mathematics Subject Classification ID

Classification and discrimination; cluster analysis (statistical aspects) (62H30) Applications of statistics to biology and medical sciences; meta analysis (62P10) Biomedical imaging and signal processing (92C55)

Review text

Summary: The aim of this paper is to develop an automated system for epileptic seizure prediction from intracranial EEG signals based on Hilbert-Huang transform (HHT) and Bayesian classifiers. Proposed system includes decomposition of the signals into intrinsic mode functions for obtaining features and use of Bayesian networks with correlation based feature selection for binary classification of preictal and interictal recordings. The system was trained and tested on Freiburg EEG database. 58 hours of preictal data, 40-minute data blocks prior to each of 87 seizures collected from 21 patients, and 503.1 hours of interictal data were examined resulting in 96.55\% sensitivity with 0.21 false alarms per hour, 13.896\% average proportion of time spent in warning, and 33.21 minutes of average detection latency using 30-second EEG segments with 50\% overlap and a simple postprocessing technique resulting in a decision (a seizure is expected/not expected) every 5 minutes. High sensitivity and low false positive rate with reasonable detection latency show that HHT based features are acceptable for patient specific seizure prediction from intracranial EEG data. Time spent for testing an EEG segment was 4.1451 seconds on average, which makes the system viable for use in real-time seizure control systems.

Recommendations

• Comparison of three nonlinear seizure prediction methods by means of the seizure prediction characteristic
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Cites work

• Bayesian network classifiers
• Comparison of three nonlinear seizure prediction methods by means of the seizure prediction characteristic
• Testing statistical significance of multivariate time series analysis techniques for epileptic seizure prediction
• The empirical mode decomposition and the Hilbert spectrum for nonlinear and non-stationary time series analysis
• Wrappers for feature subset selection

Cited in

(3)

• The prediction of EEG signals using a feedback-structured adaptive rational function filter
• Automated epilepsy prediction by means of visual perception testing and digital EEG processing data
• Toward an autonomous platform for spatio-temporal EEG-signal analysis based on cellular nonlinear networks

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