Precision of maximum likelihood estimation in adaptive designs

DOI10.1002/SIM.6761MaRDI QIDQ6964975zbMATH OpenFDO

Authors Alexandra Christine Graf, Georg Gutjahr, Werner Brannath

Publication date 4 July 2025

Published in Statistics in Medicine (Search for Journal in Brave)

Copyright license Creative Commons Attribution 3.0 Unported

Full work available at URL https://doi.org/10.1002/SIM.6761

zbMATH Keywords

adaptive designsmaximum likelihood estimationsample size reassessmenttreatment selection

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10)

Cites work

• A comparison of methods for adaptive treatment selection
• A Multiple Comparison Procedure for Comparing Several Treatments with a Control
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• Cuba -- a library for multidimensional numerical integration
• Designed Extension of Studies Based on Conditional Power
• Estimation following selection of the largest of two normal means
• Evaluation of Experiments with Adaptive Interim Analyses
• Maximum type 1 error rate inflation in multiarmed clinical trials with adaptive interim sample size modifications
• Point estimates and confidence regions for sequential trials involving selection
• Shrinkage estimation in two-stage adaptive designs with midtrial treatment selection
• Two stage conditionally unbiased estimators of the selected mean
• Unbiased estimation of selected treatment means in two-stage trials

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