Multi-scale, multi-resolution brain cancer modeling
From MaRDI portal
(Redirected from Publication:1013136)
Abstract: In advancing discrete-based computational cancer models towards clinical applications, one faces the dilemma of how to deal with an ever growing amount of biomedical data that ought to be incorporated eventually in one form or another. Model scalability becomes of paramount interest. In an effort to start addressing this critical issue, here, we present a novel multi-scale and multi-resolution agent-based in silico glioma model. While "multi-scale" refers to employing an epidermal growth factor receptor (EGFR)-driven molecular network to process cellular phenotypic decisions within the micro-macroscopic environment, "multi-resolution" is achieved through algorithms that classify cells to either active or inactive spatial clusters, which determine the resolution they are simulated at. The aim is to assign computational resources where and when they matter most for maintaining or improving the predictive power of the algorithm, onto specific tumor areas and at particular times. Using a previously described 2D brain tumor model, we have developed four different computational methods for achieving the multi-resolution scheme, three of which are designed to dynamically train on the high-resolution simulation that serves as control. To quantify the algorithms' performance, we rank them by weighing the distinct computational time savings of the simulation runs versus the methods' ability to accurately reproduce the high-resolution results of the control. Finally, to demonstrate the flexibility of the underlying concept, we show the added value of combining the two highest-ranked methods.
Recommendations
- Computational modeling of brain tumors: discrete, continuum or hybrid?
- Multiscale agent-based cancer modeling
- Simulating brain tumor heterogeneity with a multiscale agent-based model: Linking molecular signatures, phenotypes and expansion rate
- Computational Methods and Results for Structured Multiscale Models of Tumor Invasion
- A multiscale modeling approach to glioma invasion with therapy
Cites work
- scientific article; zbMATH DE number 726524 (Why is no real title available?)
- A mathematical model of the effects of hypoxia on the cell-cycle of normal and cancer cells
- Development of a three-dimensional multiscale agent-based tumor model: simulating gene-protein interaction profiles, cell phenotypes and multicellular patterns in brain cancer
- Evolutionary game theory in an agent-based brain tumor model: exploring the `genotype-phenotype' link
- Mathematical modelling of cancer cell invasion of tissue: local and non-local models and the effect of adhesion
- Modeling the VEGF-Bcl-2-CXCL8 pathway in intratumoral agiogenesis
- Multiscale agent-based cancer modeling
- Nonlinear simulation of tumor growth
- Simulating brain tumor heterogeneity with a multiscale agent-based model: Linking molecular signatures, phenotypes and expansion rate
- Simulating the impact of a molecular `decision-process' on cellular phenotype and multicellular patterns in brain tumors
- The effects of EGF-receptor density on multiscale tumor growth patterns
- The impact of ``search precision in an agent-based tumor model
Cited in
(8)- MODELLING THREE-DIMENSIONAL GROWTH OF BRAIN TUMOURS FROM TIME SERIES OF SCANS
- Computational modeling of brain tumors: discrete, continuum or hybrid?
- Multiscale cancer modeling: In the line of fast simulation and chemotherapy
- Employing graphics processing unit technology, alternating direction implicit method and domain decomposition to speed up the numerical diffusion solver for the biomedical engineering research
- Computer implementation of a new therapeutic model for GBM tumor
- Hybrid modelling in biology: a classification review
- An advanced discrete state-discrete event multiscale simulation model of the response of a solid tumor to chemotherapy: mimicking a clinical study
- Development of a three-dimensional multiscale agent-based tumor model: simulating gene-protein interaction profiles, cell phenotypes and multicellular patterns in brain cancer
This page was built for publication: Multi-scale, multi-resolution brain cancer modeling
Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q1013136)
