Multi-scale, multi-resolution brain cancer modeling
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Publication:1013136
DOI10.1016/J.MATCOM.2008.09.007zbMATH Open1158.92030DBLPjournals/mcs/ZhangCD09arXiv0806.3980OpenAlexW1975801476WikidataQ42119879 ScholiaQ42119879MaRDI QIDQ1013136FDOQ1013136
L. Leon Chen, Thomas S. Deisboeck, Le Zhang
Publication date: 17 April 2009
Published in: Mathematics and Computers in Simulation (Search for Journal in Brave)
Abstract: In advancing discrete-based computational cancer models towards clinical applications, one faces the dilemma of how to deal with an ever growing amount of biomedical data that ought to be incorporated eventually in one form or another. Model scalability becomes of paramount interest. In an effort to start addressing this critical issue, here, we present a novel multi-scale and multi-resolution agent-based in silico glioma model. While "multi-scale" refers to employing an epidermal growth factor receptor (EGFR)-driven molecular network to process cellular phenotypic decisions within the micro-macroscopic environment, "multi-resolution" is achieved through algorithms that classify cells to either active or inactive spatial clusters, which determine the resolution they are simulated at. The aim is to assign computational resources where and when they matter most for maintaining or improving the predictive power of the algorithm, onto specific tumor areas and at particular times. Using a previously described 2D brain tumor model, we have developed four different computational methods for achieving the multi-resolution scheme, three of which are designed to dynamically train on the high-resolution simulation that serves as control. To quantify the algorithms' performance, we rank them by weighing the distinct computational time savings of the simulation runs versus the methods' ability to accurately reproduce the high-resolution results of the control. Finally, to demonstrate the flexibility of the underlying concept, we show the added value of combining the two highest-ranked methods.
Full work available at URL: https://arxiv.org/abs/0806.3980
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Medical applications (general) (92C50) PDEs in connection with biology, chemistry and other natural sciences (35Q92) Computational methods for problems pertaining to biology (92-08)
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Cited In (6)
- Employing graphics processing unit technology, alternating direction implicit method and domain decomposition to speed up the numerical diffusion solver for the biomedical engineering research
- Development of a three-dimensional multiscale agent-based tumor model: simulating gene-protein interaction profiles, cell phenotypes and multicellular patterns in brain cancer
- Computer implementation of a new therapeutic model for GBM tumor
- Hybrid Modelling in Biology: a Classification Review
- MODELLING THREE-DIMENSIONAL GROWTH OF BRAIN TUMOURS FROM TIME SERIES OF SCANS
- Multiscale cancer modeling: In the line of fast simulation and chemotherapy
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