Simulating brain tumor heterogeneity with a multiscale agent-based model: Linking molecular signatures, phenotypes and expansion rate

DOI10.1016/j.mcm.2008.05.011zbMath1165.92314arXivq-bio/0612037OpenAlexW2068887552WikidataQ43166122 ScholiaQ43166122MaRDI QIDQ2389901

Thomas S. Deisboeck, Zhihui Wang, Costas G. Strouthos, Le Zhang

Publication date: 20 July 2009

Published in: Mathematical and Computer Modelling (Search for Journal in Brave)

Full work available at URL: https://arxiv.org/abs/q-bio/0612037

zbMATH Keywords

agent-based modelgliomacancer heterogeneityepidermal growth factor receptor

Mathematics Subject Classification ID

Medical applications (general) (92C50) Genetics and epigenetics (92D10) Computational methods for problems pertaining to biology (92-08)

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Cites Work

• Simulating the impact of a molecular `decision-process' on cellular phenotype and multicellular patterns in brain tumors
• Complex dynamics of tumors: modeling an emerging brain tumor system with coupled reaction-diffusion equations
• Simulating the time series of a selected gene expression profile in an agent-based tumor model
• The impact of ``search precision in an agent-based tumor model
• An error catastrophe in cancer?
• A mathematical model of the effects of hypoxia on the cell-cycle of normal and cancer cells
• The effects of EGF-receptor density on multiscale tumor growth patterns
• Development of a three-dimensional multiscale agent-based tumor model: simulating gene-protein interaction profiles, cell phenotypes and multicellular patterns in brain cancer

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