Modeling and identification of endocrine-metabolic systems. Theoretical aspects and their importance in practice

DOI10.1016/0025-5564(84)90113-5MaRDI QIDQ1068752zbMATH OpenOpenAlexFDO

Authors Claudio Cobelli

Publication date 1984

Published in Mathematical Biosciences (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1016/0025-5564(84)90113-5

zbMATH Keywords

a priori identifiabilitycompartmental and noncompartmental modelsglucose-insulin systemketone body metabolismModel validationmodeling of endocrine- metabolic systemsoptimal experiment design

Mathematics Subject Classification ID

Physiological, cellular and medical topics (92Cxx) System identification (93B30)

Review text

Guidelines for the kinetic modeling of endocrine-metabolic systems are discussed. Model validation is of utmost importance nowadays. In this respect concepts of a priori identifiability and optimal experiment design are studied. The theory is illustrated on the glucose-insulin system and on ketone body metabolism.

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Cites work

• A model of glucose kinetics and their control by insulin, compartmental and noncompartmental approaches
• An integrated mathematical model of the dynamics of blood glucose and its hormonal control
• Complete parameter bounds and quasiidentifiability conditions for a class of unidentifiable linear systems
• scientific article; zbMATH DE number 3922420 (Why is no real title available?)
• scientific article; zbMATH DE number 3750819 (Why is no real title available?)
• Identifiability from parameter bounds. Structural and numerical aspects
• Minimal sampling schedules for identification of dynamic models of metabolic systems of clinical interest: Case studies for two liver function tests
• Unidentifiable compartmental models: What to do?

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