Quantification of multiple tumor clones using gene array and sequencing data

DOI10.1214/17-AOAS1026zbMATH Open1391.62207OpenAlexW2739169896WikidataQ47109662 ScholiaQ47109662MaRDI QIDQ148528FDOQ148528

Authors: Yichen Cheng, James Y. Dai, Thomas G. Paulson, Xiaoyu Wang, Xiaohong Li, Brian J. Reid, Charles Kooperberg, Yichen Cheng, James Y. Dai, Thomas G. Paulson, Brian J. Reid, Charles Kooperberg, Xiaoyu Wang, Xiaohong Li 

Publication date: 1 June 2017

Published in: The Annals of Applied Statistics (Search for Journal in Brave)

Full work available at URL: https://projecteuclid.org/euclid.aoas/1500537731

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zbMATH Keywords

BICidentifiabilityBayesian methodcopy number aberrationintratumor heterogeneity

Mathematics Subject Classification ID

Bayesian inference (62F15) Applications of statistics to biology and medical sciences; meta analysis (62P10)

Cited In (10)

• ICeD-t provides accurate estimates of immune cell abundance in tumor samples by allowing for aberrant gene expression patterns
• PLASQ: a generalized linear model-based procedure to determine allelic dosage in cancer cells from SNP array data
• Clustering-based method for developing a genomic copy number alteration signature for predicting the metastatic potential of prostate cancer
• Allele-specific copy number estimation by whole exome sequencing
• Quantitative analysis of two-dimensional observations of premalignant clones in the presence or absence of malignant tumors
• Using somatic mutation data to test tumors for clonal relatedness
• A mixture model to characterize genomic alterations of tumors
• Joint analysis of single-cell and bulk tissue sequencing data to infer intratumor heterogeneity
• EstMix
• Tumor copy number deconvolution integrating bulk and single-cell sequencing data

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