Inverse inbreeding coefficient problems with an application to linkage analysis of recessive diseases in inbred populations

DOI10.1016/S0166-218X(00)00193-1MaRDI QIDQ1585318zbMATH OpenFDO

Authors Richa Agarwala, Leslie G. Biesecker, Alejandro A. Schäffer

Publication date 18 February 2002

Published in Discrete Applied Mathematics (Search for Journal in Brave)

zbMATH Keywords

cyclesinbreeding coefficientlinkage analysispedigreesgraphs algorithmsrecessive disease

Mathematics Subject Classification ID

Medical applications (general) (92C50) Applications of graph theory (05C90) Genetics and epigenetics (92D10) Directed graphs (digraphs), tournaments (05C20)

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• Matrix inversions for chromosomal inversions: a method to construct summary statistics in complex coalescent models
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• Modeling the effect of inbreeding among founders in linkage analysis
• Calculation of the inbreeding coefficient

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