A Class of Tests for Linkage Using Affected Pedigree Members

DOI10.2307/2533202zbMath0824.62100OpenAlexW4300942465WikidataQ46229770 ScholiaQ46229770MaRDI QIDQ4844248

Jerry W. Halpern, Alice S. Whittemore

Publication date: 13 November 1995

Published in: Biometrics (Search for Journal in Brave)

Full work available at URL: https://semanticscholar.org/paper/f113eb4d8e093a41b1f0db1804008a8cc0a184b4

zbMATH Keywords

pedigreeidentity-by-descentgenotypeconfiguration probabilityexact \(P\)-valuesmarker allele similaritytests for linkage

Mathematics Subject Classification ID

Nonparametric hypothesis testing (62G10) Applications of statistics to biology and medical sciences; meta analysis (62P10) Genetics and epigenetics (92D10)

Related Items (10)

Spectral decomposition of score functions in linkage analysis ⋮ Modeling the effect of inbreeding among founders in linkage analysis ⋮ Quantifying the fraction of missing information for hypothesis testing in statistical and genetic studies ⋮ Improving sequence-based genotype calls with linkage disequilibrium and pedigree information ⋮ Asymptotic estimation theory of multipoint linkage analysis under perfect marker information. ⋮ A Likelihood-Based Trait-Model-Free Approach for Linkage Detection of Binary Trait ⋮ Genetic linkage methods for quantitative traits ⋮ Allele-sharing among affected relatives: non-parametric methods for identifying genes ⋮ Solving genetic heterogeneity in extended families by identifying sub-types of complex diseases ⋮ A score test for linkage using identity by descent data from sibships

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