Optimal control formulation of pulse-based control using Koopman operator

DOI10.1016/J.AUTOMATICA.2018.01.036zbMATH Open1387.93063arXiv1707.08462OpenAlexW2736746078WikidataQ130106872 ScholiaQ130106872MaRDI QIDQ1641069FDOQ1641069

Aivar Sootla, D. Ernst, Alexandre Mauroy

Publication date: 14 June 2018

Published in: Automatica (Search for Journal in Brave)

Abstract: In many applications, and in systems/synthetic biology, in particular, it is desirable to compute control policies that force the trajectory of a bistable system from one equilibrium (the initial point) to another equilibrium (the target point), or in other words to solve the switching problem. It was recently shown that, for monotone bistable systems, this problem admits easy-to-implement open-loop solutions in terms of temporal pulses (i.e., step functions of fixed length and fixed magnitude). In this paper, we develop this idea further and formulate a problem of convergence to an equilibrium from an arbitrary initial point. We show that this problem can be solved using a static optimization problem in the case of monotone systems. Changing the initial point to an arbitrary state allows to build closed-loop, event-based or open-loop policies for the switching/convergence problems. In our derivations we exploit the Koopman operator, which offers a linear infinite-dimensional representation of an autonomous nonlinear system. One of the main advantages of using the Koopman operator is the powerful computational tools developed for this framework. Besides the presence of numerical solutions, the switching/convergence problem can also serve as a building block for solving more complicated control problems and can potentially be applied to non-monotone systems. We illustrate this argument on the problem of synchronizing cardiac cells by defibrillation. Potentially, our approach can be extended to problems with different parametrizations of control signals since the only fundamental limitation is the finite time application of the control signal.

Full work available at URL: https://arxiv.org/abs/1707.08462

zbMATH Keywords

monotone systemsKoopman operatorgenetic toggle switchgeneralized repressilatorisostables

Mathematics Subject Classification ID

Linear systems in control theory (93C05) Nonlinear systems in control theory (93C10) Control/observation systems governed by functional relations other than differential equations (such as hybrid and switching systems) (93C30) Operator-theoretic methods (93B28)

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Cited In (8)

• Optimal control formulation of pulse-based control using Koopman operator
• Towards a Perron-Frobenius theory for eventually positive operators
• Linearly Constrained Linear Quadratic Regulator from the Viewpoint of Kernel Methods
• Nonlinear observability via Koopman analysis: characterizing the role of symmetry
• Data-driven safe control via finite-time Koopman identifier
• Koopman operator-based model reduction for switched-system control of PDEs
• Koopman modeling and optimal control for microbial fed-batch fermentation with switching operators
• Phase reduction and phase-based optimal control for biological systems: a tutorial

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