Asymptotic behavior of Eigen's quasispecies model
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Abstract: We study Eigen's quasispecies model in the asymptotic regime where the length of the genotypes goes to infinity and the mutation probability goes to 0. A limiting infinite system of differential equations is obtained. We prove the convergence of the trajectories, as well as the convergence of the equilibrium solutions. We give the analogous results for a discrete-time version of Eigen's model, which coincides with a model proposed by Moran.
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Cites work
- scientific article; zbMATH DE number 3251767 (Why is no real title available?)
- A note on a more general solution of Eigen's rate equation for selection
- Abrupt transitions to tumor extinction: a phenotypic quasispecies model
- Analysis of Eigen's equations for selection of biological molecules with fluctuating mutation rates
- Convergence of a Moran model to Eigen's quasispecies model
- Genetic instability and the quasispecies model
- Global stability of genetic systems governed by mutation and selection
- Global stability of genetic systems governed by mutation and selection. II
- On Eigen's theory of the self-organization of matter and the evolution of biological macromolecules
- On the theory of selection of coupled macromolecular systems
- Quasispecies on class-dependent fitness landscapes
- Variation approach to error threshold in generic fitness landscape
Cited in
(22)- Relaxation property and stability analysis of the quasispecies models
- Structure of principal eigenvectors and genetic diversity
- Generalized quasispecies model on finite metric spaces: isometry groups and spectral properties of evolutionary matrices
- The quasispecies equation and classical population models
- Open quasispecies models: stability, optimization, and distributed extension
- scientific article; zbMATH DE number 7073821 (Why is no real title available?)
- On the relation between the Eigen model and the asexual Wright-Fisher model
- Non-Archimedean replicator dynamics and Eigen's paradox
- A stochastic version of the Eigen model
- On diffusive stability of Eigen's quasispecies model
- Convergence of a Moran model to Eigen's quasispecies model
- Some rigorous results on the eigen quasispecies model with a periodically moving sharp-peak landscape
- Schwinger boson formulation and solution of the crow-kimura and eigen models of quasispecies theory
- Eigen model version of evolution with directed migration
- Punctuated evolution for the quasispecies model
- Quasispecies on class-dependent fitness landscapes
- Asymptotic enumeration, global structure, and constrained evolution
- Expansion of error thresholds for the Moran model
- An asymptotic maximum principle for essentially linear evolution models
- A stochastic model for the evolution of a quasispecies
- The Wright-Fisher model for class-dependent fitness landscapes
- Rigorous mathematical analysis of the quasispecies model: from Manfred Eigen to the recent developments
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