Geometrical effects on nonlinear electrodiffusion in cell physiology

DOI10.1007/S00332-017-9393-2MaRDI QIDQ1685148zbMATHOpenAlexWikidataFDO

Authors J. Cartailler, D. Holcman, Zeev Schuss

Publication date 13 December 2017

Published in Journal of Nonlinear Science (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1705.02527

zbMATH Keywords

Poisson equationPoisson-Nernst-Planck equationelectrical properties of a cell

Mathematics Subject Classification ID

Laplace operator, Helmholtz equation (reduced wave equation), Poisson equation (35J05) Nonlinear boundary value problems for nonlinear elliptic equations (35J66) Biophysics (92C05)

Abstract: We report here new electrical laws, derived from nonlinear electro-diffusion theory, about the effect of the local geometrical structure, such as curvature, on the electrical properties of a cell. We adopt the Poisson-Nernst-Planck (PNP) equations for charge concentration and electric potential as a model of electro-diffusion. In the case at hand, the entire boundary is impermeable to ions and the electric field satisfies the compatibility condition of Poisson's equation. We construct an asymptotic approximation for certain singular limits to the steady-state solution in a ball with an attached cusp-shaped funnel on its surface. As the number of charge increases, they concentrate at the end of cusp-shaped funnel. These results can be used in the design of nano-pipettes and help to understand the local voltage changes inside dendrites and axons with heterogenous local geometry.

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Cited in

(5)

• Modeling the voltage distribution in a non-locally but globally electroneutral confined electrolyte medium: applications for nanophysiology
• Electro-physiology models of cells with spherical geometry with non-conducting center
• A Voronoi interface approach to cell aggregate electropermeabilization
• Steady-state voltage distribution in three-dimensional cusp-shaped funnels modeled by PNP
• On the sodium concentration diffusion with three-dimensional extracellular stimulation

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