Cell pelotons: a model of early evolutionary cell sorting, with application to slime mold \textit{Dictyostelium discoideum}

DOI10.1016/J.JTBI.2019.02.011MaRDI QIDQ1739243zbMATH OpenOpenAlexWikidataFDO

Authors Hugh Trenchard

Publication date 26 April 2019

Published in Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1902.07601

zbMATH Keywords

\textit{Dictyostelium discoideum}early evolutionary stageenergy-saving mechanismheterogeneous metabolic outputsoutput phasepelotonslime mold

Mathematics Subject Classification ID

Cell biology (92C37) Physiological, cellular and medical topics (92C99)

Abstract: A theoretical model is presented for early evolutionary cell sorting within cellular aggregates. The model involves an energy-saving mechanism and principles of collective self-organization analogous to those observed in bicycle pelotons (groups of cyclists). The theoretical framework is applied to slime-mold slugs (Dictyostelium discoideum) and incorporated into a computer simulation which demonstrates principally the sorting of cells between the anterior and posterior slug regions. The simulation relies on an existing simulation of bicycle peloton dynamics which is modified to incorporate a limited range of cell metabolic capacities among heterogeneous cells, along with a tunable energy-expenditure parameter, referred to as an 'output-level' or 'starvation-level' to reflect diminishing energetic supply, proto-cellular dynamics are modelled for three output phases: 'active', 'suffering', and 'dying or dead.' Adjusting the starvation parameter causes cell differentiation and sorting into sub-groups within the cellular aggregate. Tuning of the starvation parameter demonstrates how weak or expired cells shuffle backward within the cellular aggregate.

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Cites work

• A deceleration model for bicycle peloton dynamics and group sorting
• A simple model for phase locking of biological oscillators
• A thermodynamical model of cell distributions in the slug of cellular slime mold
• Cell sorting by differential cell motility: a model for pattern formation in \textit{Dictyostelium}
• Drafting, kissing and tumbling process of two particles with different sizes
• How cellular movement determines the collective force generated by the \textit{Dictyostelium discoideum} slug
• Hydrodynamic interaction of two swimming model micro-organisms
• Modelling of \textit{Dictyostelium discoideum} slug migration
• The peloton superorganism and protocooperative behavior

Cited in

(4)

• A thermodynamical model of cell distributions in the slug of cellular slime mold
• A simulation model of \textit{Dictyostelium discoideum} for the study of evolutionary selection mechanisms
• The peloton superorganism and protocooperative behavior
• A deceleration model for bicycle peloton dynamics and group sorting

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