Fast and slow dynamics of malaria and the S-gene frequency

DOI10.1007/S10884-004-7828-6MaRDI QIDQ1763016zbMATH OpenOpenAlexFDO

Authors Zhilan Feng, Yingfei Yi, Huanping Zhu

Publication date 18 February 2005

Published in Journal of Dynamics and Differential Equations (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1007/s10884-004-7828-6

zbMATH Keywords

singular perturbationslow and fast dynamicsslow manifold

Mathematics Subject Classification ID

Qualitative investigation and simulation of ordinary differential equation models (34C60) Singular perturbations for ordinary differential equations (34E15) Epidemiology (92D30)

Review text

The paper is devoted to the study of a model describing both malaria epidemics and human population genetics of the sickle cell. The authors rewrite the system in a singularly perturbed form, and use the singular perturbation techniques to separate the dynamics of the system. The slow manifold is constructed and the dynamics of the system on the slow manifold is investigated. The analysis of the model provides insights how malaria epidemics may have an impact on the maintenance of the sickle cell gene in a population, where malaria is prevalent.

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Cites work

• Center manifolds for invariant sets
• Disease-induced natural selection in a diploid host
• Epidemiology and genetics in the coevolution of parasites and hosts
• Geometric singular perturbation theory for ordinary differential equations
• On the persistence of spatially homogeneous solutions of a population genetics model with slow selection
• The effect of epidemics on genetic evolution

Cited in

(17)

• Predator-prey dynamics with Allee effect in prey refuge
• Differential impact of sickle cell trait on symptomatic and asymptomatic malaria
• A black swan and canard cascades in an SIR infectious disease model
• Fast and slow dynamics of malaria model with relapse
• The influence of infectious diseases on population genetics
• Coupling ecology and evolution: malaria and the \(S\)-gene across time scales
• Stability and Hopf bifurcations of nonlinear delay malaria epidemic model
• The impact of resource and temperature on Malaria transmission
• Global Analysis of Predator-Prey System with Hawk and Dove Tactics
• Malaria drug resistance: the impact of human movement and spatial heterogeneity
• A mathematical model of sickle cell genome frequency in response to selective pressure from malaria
• Bifurcation analysis of multiscale malaria model with Serratia AS1 bacteria and saturated treatment
• Parametrization of slow invariant manifolds in the model of the spread of malaria
• Global stability and Hopf bifurcation of a host–parasite system
• The role of natural recovery category in malaria dynamics under saturated treatment
• Global dynamics of a multiscale malaria model with two strains
• Qualitative study of transmission dynamics of drug-resistant malaria

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