Influence of intracellular delay on the dynamics of Hepatitis C virus

DOI10.1007/S40819-018-0519-5MaRDI QIDQ1794656zbMATH OpenOpenAlexFDO

Authors Sandip Banerjee, Ram Keval

Publication date 15 October 2018

Published in International Journal of Applied and Computational Mathematics (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1403.2063

zbMATH Keywords

stability analysisbifurcation analysisintracellular delayHepatitis C virus

Mathematics Subject Classification ID

Medical applications (general) (92C50) Medical epidemiology (92C60) Bifurcation theory for ordinary differential equations (34C23)

Abstract: In this paper we present a delay induced model for hepatitis C virus incorporating the healthy and infected hepatocytes as well as infectious and noninfectious virions. The model is mathematically analyzed and characterized, both for the steady states and the dynamical behavior of the model. It is shown that time delay does not affect the local asymptotic stability of the uninfected steady state. However, it can destabilize the endemic equilibrium, leading to Hopf bifurcation to periodic solutions with realistic data sets. The model is also validated using 12 patient data obtained from the study, conducted at the University of Sao Paulo Hospital das clinicas.

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Cited in

(5)

• Mathematical modelling for co-infection dynamics of Japanese encephalitis-dengue and influence of JE vaccine on dengue disease
• Dynamics on Hepatitis B Virus Infection In Vivo with Interval Delay
• The intracellular dynamics of hepatitis B virus (HBV) replication with reproduced virion ``re-cycling
• Dynamics of an HBV/HCV infection model with intracellular delay and cell proliferation
• The impact of time delay in the transmission of Japanese encephalitis without vaccination

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