Influence of intracellular delay on the dynamics of Hepatitis C virus
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Publication:1794656
DOI10.1007/S40819-018-0519-5zbMATH Open1397.92392arXiv1403.2063OpenAlexW2963922344MaRDI QIDQ1794656FDOQ1794656
Authors: Sandip Banerjee, Ram Keval 
Publication date: 15 October 2018
Published in: International Journal of Applied and Computational Mathematics (Search for Journal in Brave)
Abstract: In this paper we present a delay induced model for hepatitis C virus incorporating the healthy and infected hepatocytes as well as infectious and noninfectious virions. The model is mathematically analyzed and characterized, both for the steady states and the dynamical behavior of the model. It is shown that time delay does not affect the local asymptotic stability of the uninfected steady state. However, it can destabilize the endemic equilibrium, leading to Hopf bifurcation to periodic solutions with realistic data sets. The model is also validated using 12 patient data obtained from the study, conducted at the University of Sao Paulo Hospital das clinicas.
Full work available at URL: https://arxiv.org/abs/1403.2063
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Medical applications (general) (92C50) Medical epidemiology (92C60) Bifurcation theory for ordinary differential equations (34C23)
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Cited In (5)
- Mathematical modelling for co-infection dynamics of Japanese encephalitis-dengue and influence of JE vaccine on dengue disease
- Dynamics on Hepatitis B Virus Infection In Vivo with Interval Delay
- The intracellular dynamics of hepatitis B virus (HBV) replication with reproduced virion ``re-cycling
- Dynamics of an HBV/HCV infection model with intracellular delay and cell proliferation
- The impact of time delay in the transmission of Japanese encephalitis without vaccination
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