The kientics of bivalent ligand-bivalent receptor aggregation: Ring formation and the breakdown of the equivalent site approximation

DOI10.1016/0025-5564(94)00045-2MaRDI QIDQ1804830zbMATH OpenOpenAlexWikidataFDO

Authors Richard G. Posner, Carla Wofsy, Byron Goldstein

Publication date 14 September 1995

Published in Mathematical Biosciences (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1016/0025-5564(94)00045-2

zbMATH Keywords

ring formationinfinite set of coupled ordinary differential equationsbivalent ligandsaggregate size distributionbivalent receptorschain formationkinetics of aggregate formationligand concentrationsring concentrationssite approximation

Mathematics Subject Classification ID

Biochemistry, molecular biology (92C40) Physiology (general) (92C30) Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45) General theory for ordinary differential equations (34A99)

Recommendations

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• scientific article; zbMATH DE number 3885698
• Ring formation in divalent-receptor-divalent-ligand interaction: Pseudocooperative shapes of Scatchard plots
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Cites work

• Analysis of a molecular signal for cell function in algebraic reactions
• Receptor clustering on a cell surface. I. Theory of receptor cross- linking by ligands bearing two chemically identical functional groups
• Receptor clustering on a cell surface. II. Theory of receptor cross- linking by ligands bearing two chemically distinct functional groups
• Theory of equilibrium binding of a bivalent ligand to cell surface antibody: The effect of antibody heterogeneity on cross-linking

Cited in

(9)

• scientific article; zbMATH DE number 5885205 (Why is no real title available?)
• Ring formation in divalent-receptor-divalent-ligand interaction: Pseudocooperative shapes of Scatchard plots
• Analysis of biochemical equilibria relevant to the immune response: finding the dissociation constants
• Equilibrium binding of multivalent ligands to cells: Effects of cell and receptor density
• Antagonist binding in the rat muscarinic receptor: A study by docking and X-ray crystallogra\-phy
• Generalized concentration addition for ligands that bind to homodimers
• On the interaction of different types of ligands binding to the same molecule part II: systems with \(n\) to 2 and \(n\) to 3 binding sites
• Interpretation of Scatchard plots for aggregating receptor systems
• Diffusion theory can be applied to antibodies attaching to ligand sites

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