Using nonlinear model predictive control to find optimal therapeutic strategies to modulate inflammation

DOI10.3934/mbe.2010.7.739zbMath1259.92036OpenAlexW2317325462WikidataQ51637373 ScholiaQ51637373MaRDI QIDQ1942389

Jonathan E. Rubin, Judy Day, Gilles Clermont

Publication date: 19 March 2013

Published in: Mathematical Biosciences and Engineering (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.3934/mbe.2010.7.739

zbMATH Keywords

dosing controlimmuno-modulation

Mathematics Subject Classification ID

Numerical optimization and variational techniques (65K10) Control/observation systems involving computers (process control, etc.) (93C83) Medical applications (general) (92C50) Control/observation systems governed by ordinary differential equations (93C15)

Related Items (7)

Toward a model-free feedback control synthesis for treating acute inflammation ⋮ Mechanisms and points of control in the spread of inflammation: a mathematical investigation ⋮ Immune therapeutic strategies using optimal controls with \(L^{1}\) and \(L^{2}\) type objectives ⋮ Modeling of adaptive immunity uncovers disease tolerance mechanisms ⋮ Mathematical modeling of energy consumption in the acute inflammatory response ⋮ A data-driven model of the role of energy in sepsis ⋮ Combining robust state estimation with nonlinear model predictive control to regulate the acute inflammatory response to pathogen

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