Global Hopf bifurcation in networks with fast feedback cycles

DOI10.3934/DCDSS.2020344MaRDI QIDQ1995409zbMATH OpenOpenAlexFDO

Authors B. Fiedler

Publication date 23 February 2021

Published in Discrete and Continuous Dynamical Systems. Series S (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1903.09996

zbMATH Keywords

metabolicglobal bifurcationchemical reaction networksperiodic oscillationsmolecularfeedback cycles

Mathematics Subject Classification ID

Biochemistry, molecular biology (92C40) Systems biology, networks (92C42) Paths and cycles (05C38) Nonlinear oscillations and coupled oscillators for ordinary differential equations (34C15) Bifurcations of limit cycles and periodic orbits in dynamical systems (37G15)

Abstract: Autonomous sustained oscillations are ubiquitous in living and nonliving systems. As open systems, far from thermodynamic equilibrium, they defy entropic laws which mandate convergence to stationarity. We present structural conditions on network cycles which support global Hopf bifurcation, i.e. global bifurcation of non-stationary time-periodic solutions from stationary solutions. Specifically, we show how monotone feedback cycles of the linearization at stationary solutions give rise to global Hopf bifurcation, for sufficiently dominant coefficients along the cycle. We include four example networks which feature such strong feedback cycles of length three and larger: Oregonator chemical reaction networks, Lotka-Volterra ecological population dynamics, citric acid cycles, and a circadian gene regulatory network in mammals. Reaction kinetics in our approach are not limited to mass action or Michaelis-Menten type.

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Cited in

(7)

• Feedback-induced self-oscillations in large interacting systems subjected to phase transitions
• Feedback mechanisms for global oscillations in Luré systems
• Global dynamics of the smallest chemical reaction system with Hopf bifurcation
• Structural Conditions for Saddle-Node Bifurcations in Chemical Reaction Networks
• Asymptotic analysis of bifurcations in feedforward networks
• Amplified Hopf bifurcations in feed-forward networks
• Good and bad children in metabolic networks

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