Good and bad children in metabolic networks

DOI10.3934/MBE.2020388zbMATH Open1471.92130OpenAlexW3042403709WikidataQ104619385 ScholiaQ104619385MaRDI QIDQ1979615FDOQ1979615

Authors: Nicola Vassena 

Publication date: 3 September 2021

Published in: Mathematical Biosciences and Engineering (Search for Journal in Brave)

Abstract: Equilibrium bifurcations arise from sign changes of Jacobian determinants, as parameters are varied. Therefore we address the Jacobian determinant for metabolic networks with general reaction kinetics. Our approach is based on the concept of Child Selections: each (mother) metabolite is mapped, injectively, to one of those (child) reactions that it drives as an input. Our analysis distinguishes reaction network Jacobians with constant sign from the bifurcation case, where that sign depends on specific reaction rates. In particular we distinguish "good" Child Selections, which do not affect the sign, from more interesting and mischievous "bad" children, which gang up towards sign changes, instability, and bifurcation.

Full work available at URL: https://arxiv.org/abs/1905.12272

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zbMATH Keywords

metabolic networksstructural analysissaddle-node bifurcationJacobian determinantmultistationaritystability change

Mathematics Subject Classification ID

Biochemistry, molecular biology (92C40) Systems biology, networks (92C42)

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Cited In (3)

• Sign‐sensitivity of metabolic networks: Which structures determine the sign of the responses
• Structural Conditions for Saddle-Node Bifurcations in Chemical Reaction Networks
• Sensitivity of Steady States in Networks with Application to Markov Chains and Chemical Reaction Networks

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