Sign patterns for chemical reaction networks

DOI10.1007/S10910-009-9579-4zbMATH Open1197.92061arXiv0904.2960OpenAlexW2003166096MaRDI QIDQ848166FDOQ848166

Authors: J. William Helton, Vitaly Katsnelson, Igor Klep 

Publication date: 2 March 2010

Published in: Journal of Mathematical Chemistry (Search for Journal in Brave)

Abstract: Most differential equations found in chemical reaction networks (CRNs) have the form $dx/dt=f(x)=Sv(x)$, where $x$ lies in the nonnegative orthant, where $S$ is a real matrix (the stoichiometric matrix) and $v$ is a column vector consisting of real-valued functions having a special relationship to $S$. Our main interest will be in the Jacobian matrix, $f^{\prime }(x)$, of $f(x)$, in particular in whether or not each entry $f^{\prime }(x{)}_{ij}$ has the same sign for all $x$ in the orthant, i.e., the Jacobian respects a sign pattern. In other words species $x_j$ always acts on species $x_i$ in an inhibitory way or its action is always excitatory. In Helton, Klep, Gomez we gave necessary and sufficient conditions on the species-reaction graph naturally associated to $S$ which guarantee that the Jacobian of the associated CRN has a sign pattern. In this paper, given $S$ we give a construction which adds certain rows and columns to $S$, thereby producing a stoichiometric matrix $widehatS$ corresponding to a new CRN with some added species and reactions. The Jacobian for this CRN based on $hatS$ has a sign pattern. The equilibria for the $S$ and the $hatS$ based CRN are in exact one to one correspondence with each equilibrium $e$ for the original CRN gotten from an equilibrium $hate$ for the new CRN by removing its added species. In our construction of a new CRN we are allowed to choose rate constants for the added reactions and if we choose them large enough the equilibrium $hate$ is locally asymptotically stable if and only if the equilibrium $e$ is locally asymptotically stable. Further properties of the construction are shown, such as those pertaining to conserved quantities and to how the deficiencies of the two CRNs compare.

Full work available at URL: https://arxiv.org/abs/0904.2960

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zbMATH Keywords

sign patternchemical reaction networksigned matrix

Mathematics Subject Classification ID

Dynamical systems in biology (37N25) Basic linear algebra (15A99) Classical flows, reactions, etc. in chemistry (92E20) General theory for ordinary differential equations (34A99)

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Cited In (4)

• Sign conditions for injectivity of generalized polynomial maps with applications to chemical reaction networks and real algebraic geometry
• Critical mass curves for a short-ranged chemical signaling loop
• FRONTIER DIAGRAMS: PARTITION OF PHASE SPACE ACCORDING TO THE SIGNS OF EIGENVALUES OR SIGN PATTERNS OF THE CIRCUITS
• Simplifying the Jacobian criterion for precluding multistationarity in chemical reaction networks

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