Homotopy methods for counting reaction network equilibria
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Abstract: Dynamical system models of complex biochemical reaction networks are usually high-dimensional, nonlinear, and contain many unknown parameters. In some cases the reaction network structure dictates that positive equilibria must be unique for all values of the parameters in the model. In other cases multiple equilibria exist if and only if special relationships between these parameters are satisfied. We describe methods based on homotopy invariance of degree which allow us to determine the number of equilibria for complex biochemical reaction networks and how this number depends on parameters in the model.
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Cites work
- PMatrix Properties, Injectivity, and Stability in Chemical Reaction Systems
- A passivity-based stability criterion for a class of biochemical reaction networks
- A Petri net approach to the study of persistence in chemical reaction networks
- Determinant Expansions of Signed Matrices and of Certain Jacobians
- Diagonal stability of a class of cyclic systems and its connection with the secant criterion
- scientific article; zbMATH DE number 4017400 (Why is no real title available?)
- scientific article; zbMATH DE number 3702461 (Why is no real title available?)
- scientific article; zbMATH DE number 3574436 (Why is no real title available?)
- Mathematical physiology
- Multiple Equilibria in Complex Chemical Reaction Networks: I. The Injectivity Property
- Multiple Equilibria in Complex Chemical Reaction Networks: II. The Species-Reaction Graph
- Structure and stability of certain chemical networks and applications to the kinetic proofreading model of T-cell receptor signal transduction
- The existence and uniqueness of steady states for a class of chemical reaction networks
- The secant condition for instability in biochemical feedback control. I: The role of cooperativity and saturability
- Understanding bistability in complex enzyme-driven reaction networks
Cited in
(28)- Atoms of multistationarity in chemical reaction networks
- Symbolic analysis of multiple steady states in a MAPK chemical reaction network
- Mixed volume of small reaction networks
- Classification of infinitesimal homeostasis in four-node input-output networks
- The kinetic space of multistationarity in dual phosphorylation
- Graph-theoretic analysis of multistationarity using degree theory
- The number of equilibrium points of perturbed nonlinear positive dynamical systems
- A deficiency-based approach to parametrizing positive equilibria of biochemical reaction systems
- Multistationarity in structured reaction networks
- On the existence of the positive steady states of weakly reversible deficiency-one mass action systems
- Equilibria and stability of a class of positive feedback loops. Mathematical analysis and its application to caspase-dependent apoptosis
- On the dependence of the existence of the positive steady states on the rate coefficients for deficiency-one mass action systems: single linkage class
- Some results on injectivity and multistationarity in chemical reaction networks
- Complex-linear invariants of biochemical networks
- Algebra and geometry in the study of enzymatic cascades
- Analysis of reaction network systems using tropical geometry
- Vector-Space Methods and Kirchhoff Graphs for Reaction Networks
- Enumeration approach to computing chemical equilibria
- Notes on the deficiency-one theorem: multiple linkage classes
- The inheritance of nondegenerate multistationarity in chemical reaction networks
- Graphical methods for analysing feedback in biological networks -- a survey
- Sign conditions for injectivity of generalized polynomial maps with applications to chemical reaction networks and real algebraic geometry
- scientific article; zbMATH DE number 7774177 (Why is no real title available?)
- Parameter Region for Multistationarity in \({\boldsymbol{n-}}\)Site Phosphorylation Networks
- Nonlinear algebra and applications
- Multistability of small zero-one reaction networks
- Positive equilibria in mass action networks: geometry and bounds
- Sign patterns for chemical reaction networks
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