Gain and loss of function mutations in biological chemical reaction networks: a mathematical model with application to colorectal cancer cells

DOI10.1007/s00285-021-01607-0zbMath1466.92062arXiv2004.02632OpenAlexW3159322021WikidataQ113905526 ScholiaQ113905526MaRDI QIDQ2030258

Michele Piana, Sara Sommariva, Giacomo Caviglia

Publication date: 7 June 2021

Published in: Journal of Mathematical Biology (Search for Journal in Brave)

Full work available at URL: https://arxiv.org/abs/2004.02632

zbMATH Keywords

reaction kineticscolorectal cancer cellsG1-S transition pointgain of function mutationsloss of function mutationssynthetic cell biology

Mathematics Subject Classification ID

Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45) Cell biology (92C37) Systems biology, networks (92C42)

Related Items (1)

Combined Newton-gradient method for constrained root-finding in chemical reaction networks

Uses Software

• Matlab
• ode23
• ode45
• Ode15s
• ode113
• ode23s
• MATLAB ODE suite

Cites Work

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• The existence and uniqueness of steady states for a class of chemical reaction networks
• Modeling Growth in Biological Materials
• The MATLAB ODE Suite
• Sensitivity and Robustness in Chemical Reaction Networks
• Inverse problems in systems biology
• Inverse problems in biomedical imaging: modeling and methods of solution
• Modeling and analysis of mass-action kinetics

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