Sign-sensitivities for reaction networks: an algebraic approach

DOI10.3934/MBE.2019414zbMATH Open1470.92117arXiv1908.11655OpenAlexW2973201695WikidataQ91168142 ScholiaQ91168142MaRDI QIDQ2045593FDOQ2045593

Authors: Elisenda Feliu 

Publication date: 13 August 2021

Published in: Mathematical Biosciences and Engineering (Search for Journal in Brave)

Abstract: This paper presents an algebraic framework to study sign-sensitivities for reaction networks modeled by means of systems of ordinary differential equations. Specifically, we study the sign of the derivative of the concentrations of the species in the network at steady state with respect to a small perturbation on the parameter vector. We provide a closed formula for the derivatives that accommodates common perturbations, and illustrate its form with numerous examples. We argue that, mathematically, the study of the response to the system with respect to changes in total amounts is not well posed, and that one should rather consider perturbations with respect to the initial conditions. We find a sign-based criterion to determine, without computing the sensitivities, whether the sign depends on the steady state and parameters of the system. This is based on earlier results of so-called injective networks. Finally, we address systems with multiple steady states and the restriction to stable steady states.

Full work available at URL: https://arxiv.org/abs/1908.11655

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zbMATH Keywords

sensitivitysteady statesystems biologyperturbationreaction networkmass-action

Mathematics Subject Classification ID

Biochemistry, molecular biology (92C40) Qualitative investigation and simulation of ordinary differential equation models (34C60) Systems biology, networks (92C42)

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Cited In (4)

• Sign‐sensitivity of metabolic networks: Which structures determine the sign of the responses
• Local and global robustness at steady state
• Sensitivity of Steady States in Networks with Application to Markov Chains and Chemical Reaction Networks
• Title not available (Why is that?)

Uses Software

• MESSI

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