An algebraic approach to signaling cascades with \(n\) layers

DOI10.1007/s11538-011-9658-0zbMath1244.92015arXiv1008.0431WikidataQ51574915 ScholiaQ51574915MaRDI QIDQ417317

Michael Knudsen, Carsten Wiuf, Elisenda Feliu, Lars Nørvang Andersen

Publication date: 14 May 2012

Published in: Bulletin of Mathematical Biology (Search for Journal in Brave)

Full work available at URL: https://arxiv.org/abs/1008.0431

zbMATH Keywords

rational functions; mass action kinetics; futile cycle; posttranslational modification; sequestration; stimulus-response

Mathematics Subject Classification ID

92C55: Biomedical imaging and signal processing

37N25: Dynamical systems in biology

92C40: Biochemistry, molecular biology

92C37: Cell biology

34A99: General theory for ordinary differential equations

Related Items

Realistic enzymology for post-translational modification: zero-order ultrasensitivity revisited, The effect of site-to-site variability in ultrasensitive dose responses, The steady-state degree and mixed volume of a chemical reaction network, Implicit dose-response curves, Regions of multistationarity in cascades of Goldbeter-Koshland loops, Exact analysis of intrinsic qualitative features of phosphorelays using mathematical models, Variable elimination in post-translational modification reaction networks with mass-action kinetics, Monostationarity and multistationarity in tree networks of Goldbeter-Koshland loops, Sign-sensitivities for reaction networks: an algebraic approach, Joining and decomposing reaction networks, MAPK's networks and their capacity for multistationarity due to toric steady states, A discrete dynamical system approach to pathway activation profiles of signaling cascades

Cites Work

• On the number of steady states in a multiple futile cycle
• The rational parameterisation theorem for multisite post-translational modification systems
• Translation-invariant monotone systems, and a global convergence result for enzymatic futile cycles
• Multistationarity in the activation of a MAPK: parametrizing the relevant region in parameter space
• Bistability in cell signaling: How to make continuous processes discontinuous, and reversible processes irreversible
• Multiple Equilibria in Complex Chemical Reaction Networks: Semiopen Mass Action Systems
• Introduction to Applied Nonlinear Dynamical Systems and Chaos
• Multiple Equilibria in Complex Chemical Reaction Networks: I. The Injectivity Property
• Multiple Equilibria in Complex Chemical Reaction Networks: II. The Species-Reaction Graph