Stochastic modeling of in vitro bactericidal potency

DOI10.1007/S11538-021-00967-4MaRDI QIDQ2060039zbMATH OpenOpenAlexWikidataFDO

Authors Anita Bogdanov, Peter Kevei, Máté Szalai, Dezső Virok

Publication date 13 December 2021

Published in Bulletin of Mathematical Biology (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/2104.11525

zbMATH Keywords

\textit{Chlamydia}asymptotically normal estimatorMICmultitype Galton-Watson processquantitative PCR

Mathematics Subject Classification ID

Applications of branching processes (60J85) Microbiology (92C70)

Abstract: We provide a Galton--Watson model for the growth of a bacterial population in the presence of antibiotics. We assume that bacterial cells either die or duplicate, and the corresponding probabilities depend on the concentration of the antibiotic. Assuming that the mean offspring number is given by $$ for some $$, where $c$ stands for the antibiotic concentration we obtain weakly consistent, asymptotically normal estimator both for $$ and for the minimal inhibitory concentration (MIC), a relevant parameter in pharmacology. We apply our method to real data, where emph{Chlamydia trachomatis} bacteria was treated by azithromycin and ciprofloxacin. For the measurements of emph{Chlamydia} growth quantitative PCR technique was used. The 2-parameter model fits remarkably well to the biological data.

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Cites work

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• Branching processes in biology
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• Limit theorems for decomposable multi-dimensional Galton-Watson processes
• Optimal proliferation and differentiation of Chlamydia Trachomatis
• Stochastic chlamydia dynamics and optimal spread

Cited in

(13)

• A model of the complex response of \textit{Staphylococcus aureus} to methicillin
• Modelling conjugation with stochastic differential equations
• Deterministic and stochastic modelling of endosome escape by staphylococcus aureus: ``quorum sensing by a single bacterium
• Application of growth rate from kinetic model to calculate stochastic growth of a bacteria population at low contamination level
• Modelling the stability of Stx lysogens
• A Bayesian approach to the semiparametric estimation of a minimum inhibitory concentration distribution
• Stochastic modeling of pseudomonas syringae growth in the phyllosphere
• scientific article; zbMATH DE number 888923 (Why is no real title available?)
• Multitype branching processes in random environment
• A stochastic formulation of the Gompertzian growth model for \textit{in vitro} bactericidal kinetics: parameter estimation and extinction probability
• Using stochastic cell division and death to probe minimal units of cellular replication
• Branching model with state dependent offspring distribution for chlamydia spread
• A stochastic model of bacterial spore germination

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