Numerical investigations of the bulk-surface wave pinning model

DOI10.1016/J.MBS.2022.108925zbMATH Open1504.35580arXiv2210.13972OpenAlexW4307814007MaRDI QIDQ2103609FDOQ2103609

Authors: Davide Cusseddu, Anotida Madzvamuse 

Publication date: 9 December 2022

Published in: Mathematical Biosciences (Search for Journal in Brave)

Abstract: The bulk-surface wave pinning model is a reaction-diffusion system for studying cell polarisation. It is constituted by a surface reaction-diffusion equation, coupled to a bulk diffusion equation with a non-linear boundary condition. Cell polarisation arises as the surface component develops specific patterns. Since proteins diffuse much faster in the cell interior than on the membrane, in the literature, the bulk component is often assumed to be spatially homogeneous. { e Therefore, the model can be reduced to a single surface equation}. However, { e in real applications} a spatially non-uniform bulk component might be an important player to take into account. In this paper, we study, through numerical computations, the role of the bulk component and, more specifically, how different bulk diffusion rates might affect the polarisation response. We find that the bulk component is indeed a key factor in { e determining the surface polarisation response}. Moreover, for certain geometries, it is the spatial heterogeneity of the bulk component that triggers the polarisation response, which might not be possible in a reduced model. Understanding how polarisation depends on bulk diffusivity might be crucial when studying models of migrating cells, which are naturally subject to domain deformation.

Full work available at URL: https://arxiv.org/abs/2210.13972

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zbMATH Keywords

pattern formationcell polarisationbulk-surface finite elementbulk-surface reaction-diffusion systemwave pinning

Mathematics Subject Classification ID

Mathematical modeling or simulation for problems pertaining to biology (92-10) Pattern formations in context of PDEs (35B36) Reaction-diffusion equations (35K57) PDEs in connection with biology, chemistry and other natural sciences (35Q92) PDEs on manifolds (35R01) Finite difference methods for initial value and initial-boundary value problems involving PDEs (65M06) Finite element, Rayleigh-Ritz and Galerkin methods for initial value and initial-boundary value problems involving PDEs (65M60) Finite element, Rayleigh-Ritz and Galerkin methods for boundary value problems involving PDEs (65N30) Software, source code, etc. for problems pertaining to biology (92-04) Computational methods for problems pertaining to biology (92-08) Cell biology (92C37) Software, source code, etc. for problems pertaining to numerical analysis (65-04) Applications of PDEs on manifolds (58J90)

Cites Work

• Gmsh: a 3-D finite element mesh generator with built-in pre- and post-processing facilities
• Singular perturbation theory of traveling waves in excitable media (A review)
• Global Existence of Solutions to Reaction-Diffusion Systems with Mass Transport Type Boundary Conditions
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Cited In (3)

• Theoretical analysis of the density wave in a new continuum model and numerical simulation
• In memory of Edmund John Crampin: multi-scale and multi-physics phenomena in biology
• A bulk-surface mechanobiochemical modelling approach for single cell migration in two-space dimensions

Uses Software

• Gmsh
• FEniCS

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