Numerical investigations of the bulk-surface wave pinning model

DOI10.1016/J.MBS.2022.108925MaRDI QIDQ2103609zbMATH OpenOpenAlexFDO

Authors Davide Cusseddu, Anotida Madzvamuse

Publication date 9 December 2022

Published in Mathematical Biosciences (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/2210.13972

zbMATH Keywords

pattern formationcell polarisationbulk-surface finite elementbulk-surface reaction-diffusion systemwave pinning

Mathematics Subject Classification ID

Mathematical modeling or simulation for problems pertaining to biology (92-10) Pattern formations in context of PDEs (35B36) Reaction-diffusion equations (35K57) PDEs in connection with biology, chemistry and other natural sciences (35Q92) PDEs on manifolds (35R01) Finite difference methods for initial value and initial-boundary value problems involving PDEs (65M06) Finite element, Rayleigh-Ritz and Galerkin methods for initial value and initial-boundary value problems involving PDEs (65M60) Finite element, Rayleigh-Ritz and Galerkin methods for boundary value problems involving PDEs (65N30) Software, source code, etc. for problems pertaining to biology (92-04) Computational methods for problems pertaining to biology (92-08) Cell biology (92C37) Software, source code, etc. for problems pertaining to numerical analysis (65-04) Applications of PDEs on manifolds (58J90)

Abstract: The bulk-surface wave pinning model is a reaction-diffusion system for studying cell polarisation. It is constituted by a surface reaction-diffusion equation, coupled to a bulk diffusion equation with a non-linear boundary condition. Cell polarisation arises as the surface component develops specific patterns. Since proteins diffuse much faster in the cell interior than on the membrane, in the literature, the bulk component is often assumed to be spatially homogeneous. { e Therefore, the model can be reduced to a single surface equation}. However, { e in real applications} a spatially non-uniform bulk component might be an important player to take into account. In this paper, we study, through numerical computations, the role of the bulk component and, more specifically, how different bulk diffusion rates might affect the polarisation response. We find that the bulk component is indeed a key factor in { e determining the surface polarisation response}. Moreover, for certain geometries, it is the spatial heterogeneity of the bulk component that triggers the polarisation response, which might not be possible in a reduced model. Understanding how polarisation depends on bulk diffusivity might be crucial when studying models of migrating cells, which are naturally subject to domain deformation.

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Cites work

• A computational model of cell polarization and motility coupling mechanics and biochemistry
• A coupled bulk-surface model for cell polarisation
• Bulk-surface virtual element method for systems of PDEs in two-space dimensions
• Front blocking and propagation in cylinders with varying cross section
• Global existence of solutions to reaction-diffusion systems with mass transport type boundary conditions
• Gmsh: a 3-D finite element mesh generator with built-in pre- and post-processing facilities
• Singular perturbation theory of traveling waves in excitable media (A review)
• Traveling and standing fronts on curved surfaces

Cited in

(5)

• Theoretical analysis of the density wave in a new continuum model and numerical simulation
• A coupled bulk-surface model for cell polarisation
• In memory of Edmund John Crampin: multi-scale and multi-physics phenomena in biology
• A bulk-surface reaction-diffusion system for cell polarization
• A bulk-surface mechanobiochemical modelling approach for single cell migration in two-space dimensions

Describes a project that uses

Uses Software

• FEniCS
• Gmsh

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