A coupled bulk-surface model for cell polarisation
From MaRDI portal
Abstract: Several cellular activities, such as directed cell migration, are coordinated by an intricate network of biochemical reactions which lead to a polarised state of the cell, in which cellular symmetry is broken, causing the cell to have a well defined front and back. Recent work on balancing biological complexity with mathematical tractability resulted in the proposal and formulation of a famous minimal model for cell polarisation, known as the wave pinning model. In this study, we present a three-dimensional generalisation of this mathematical framework through the maturing theory of coupled bulk-surface semilinear partial differential equations in which protein compartmentalisation becomes natural. We show how a local perturbation over the surface can trigger propagating reactions, eventually stopped in a stable profile by the interplay with the bulk component. We describe the behavior of the model through asymptotic and local perturbation analysis, in which the role of the geometry is investigated. The bulk-surface finite element method is used to generate numerical simulations over simple and complex geometries, which confirm our analysis, showing pattern formation due to propagation and pinning dynamics. The generality of our mathematical and computational framework allows to study more complex biochemical reactions and biomechanical properties associated with cell polarisation in multi-dimensions.
Recommendations
- Numerical investigations of the bulk-surface wave pinning model
- A bulk-surface reaction-diffusion system for cell polarization
- Asymptotic and bifurcation analysis of wave-pinning in a reaction-diffusion model for cell polarization
- Global existence for a bulk/surface model for active-transport-induced polarisation in biological cells
- A coupled bulk-surface reaction-diffusion-advection model for cell polarization
Cites work
- A computational method for the coupled solution of reaction-diffusion equations on evolving domains and manifolds: application to a model of cell migration and chemotaxis
- A computational model of cell polarization and motility coupling mechanics and biochemistry
- An efficient, nonlinear stability analysis for detecting pattern formation in reaction diffusion systems
- Analysis and simulations of coupled bulk-surface reaction-diffusion systems on exponentially evolving volumes
- Asymptotic and bifurcation analysis of wave-pinning in a reaction-diffusion model for cell polarization
- Diffusion on a curved surface coupled to diffusion in the volume: application to cell biology
- Finite element analysis for a coupled bulk-surface partial differential equation
- Finite element methods for surface PDEs
- Global existence of solutions to reaction-diffusion systems with mass transport type boundary conditions
- Gmsh: a 3-D finite element mesh generator with built-in pre- and post-processing facilities
- scientific article; zbMATH DE number 1197366 (Why is no real title available?)
- scientific article; zbMATH DE number 5681750 (Why is no real title available?)
- Nonlocal reaction—diffusion equations and nucleation
- Polarization and movement of keratocytes: a multiscale modelling approach
- Stability analysis and simulations of coupled bulk-surface reaction-diffusion systems
- Symmetry breaking in a bulk-surface reaction-diffusion model for signalling networks
- The approach of solutions of nonlinear diffusion equations to travelling front solutions
- Turing instabilities in a mathematical model for signaling networks
Cited in
(40)- Bulk-surface virtual element method for systems of PDEs in two-space dimensions
- Phytoplankton competition for nutrients and light in a stratified lake: a mathematical model connecting epilimnion and hypolimnion
- Dynamics of shadow system of a singular Gierer-Meinhardt system on an evolving domain
- Long time behavior and stable patterns in high-dimensional polarity models of asymmetric cell division
- Signaling gradients in surface dynamics as basis for planarian regeneration
- Numerical investigations of the bulk-surface wave pinning model
- Deterministic and stochastic analysis for different types of regulations in the spontaneous emergence of cell polarity
- Analysis of spontaneous emergence of cell polarity with delayed negative feedback
- A bulk-surface reaction-diffusion system for cell polarization
- Difference potentials method for models with dynamic boundary conditions and bulk-surface problems
- A moving grid finite element method applied to a mechanobiochemical model for 3D cell migration
- Turing patterning in stratified domains
- A cellular Potts energy-based approach to analyse the influence of the surface topography on single cell motility
- Cell size, mechanical tension, and GTPase signaling in the single cell
- Stability analysis of a bulk-surface reaction model for membrane protein clustering
- Global existence for a bulk/surface model for active-transport-induced polarisation in biological cells
- A model of cell surface receptor aggregation
- Cell repolarization: a bifurcation study of spatio-temporal perturbations of polar cells
- Front propagation in the shadow wave-pinning model
- A PDE-DDE model for cell polarization in fission yeast
- A Model for Cell Polarization Without Mass Conservation
- A parabolic free boundary problem arising in a model of cell polarization
- Stochastic Active-Transport Model of Cell Polarization
- A coupled bulk-surface reaction-diffusion-advection model for cell polarization
- The linear stability of symmetric spike patterns for a bulk-membrane coupled Gierer-Meinhardt model
- A conservative finite element ALE scheme for mass-conservative reaction-diffusion equations on evolving two-dimensional domains
- Virtual element method for elliptic bulk‐surface PDEs in three space dimensions
- Generation and Motion of Interfaces in a Mass-Conserving Reaction-Diffusion System
- The Bulk-Surface Virtual Element Method for Reaction-Diffusion PDEs: Analysis and Applications
- Pattern Formation Inside Living Cells
- Mathematical modeling of cell polarity establishment of budding yeast
- Analysis of bulk-surface reaction-sorption-diffusion systems with Langmuir-type adsorption
- Cell polarity and movement with reaction-diffusion and moving boundary: rigorous model analysis and robust simulations
- A bulk-surface mechanobiochemical modelling approach for single cell migration in two-space dimensions
- Pattern formation of bulk-surface reaction-diffusion systems in a ball
- Bulk-surface systems on evolving domains
- The emergence of spatial patterns for compartmental reaction kinetics coupled by two bulk diffusing species with comparable diffusivities
- A novel localized least-squares collocation method for coupled bulk-surface problems
- Existence and convergence of stochastic processes underlying a thin layer approximation of a coupled bulk-surface PDE
- Bulk-surface coupling: derivation of two models
This page was built for publication: A coupled bulk-surface model for cell polarisation
Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q2328244)
