A coupled bulk-surface model for cell polarisation
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Abstract: Several cellular activities, such as directed cell migration, are coordinated by an intricate network of biochemical reactions which lead to a polarised state of the cell, in which cellular symmetry is broken, causing the cell to have a well defined front and back. Recent work on balancing biological complexity with mathematical tractability resulted in the proposal and formulation of a famous minimal model for cell polarisation, known as the wave pinning model. In this study, we present a three-dimensional generalisation of this mathematical framework through the maturing theory of coupled bulk-surface semilinear partial differential equations in which protein compartmentalisation becomes natural. We show how a local perturbation over the surface can trigger propagating reactions, eventually stopped in a stable profile by the interplay with the bulk component. We describe the behavior of the model through asymptotic and local perturbation analysis, in which the role of the geometry is investigated. The bulk-surface finite element method is used to generate numerical simulations over simple and complex geometries, which confirm our analysis, showing pattern formation due to propagation and pinning dynamics. The generality of our mathematical and computational framework allows to study more complex biochemical reactions and biomechanical properties associated with cell polarisation in multi-dimensions.
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Cites work
- scientific article; zbMATH DE number 1197366 (Why is no real title available?)
- scientific article; zbMATH DE number 5681750 (Why is no real title available?)
- A computational method for the coupled solution of reaction-diffusion equations on evolving domains and manifolds: application to a model of cell migration and chemotaxis
- A computational model of cell polarization and motility coupling mechanics and biochemistry
- An efficient, nonlinear stability analysis for detecting pattern formation in reaction diffusion systems
- Analysis and simulations of coupled bulk-surface reaction-diffusion systems on exponentially evolving volumes
- Asymptotic and bifurcation analysis of wave-pinning in a reaction-diffusion model for cell polarization
- Diffusion on a curved surface coupled to diffusion in the volume: application to cell biology
- Finite element analysis for a coupled bulk-surface partial differential equation
- Finite element methods for surface PDEs
- Global existence of solutions to reaction-diffusion systems with mass transport type boundary conditions
- Gmsh: a 3-D finite element mesh generator with built-in pre- and post-processing facilities
- Nonlocal reaction—diffusion equations and nucleation
- Polarization and movement of keratocytes: a multiscale modelling approach
- Stability analysis and simulations of coupled bulk-surface reaction-diffusion systems
- Symmetry breaking in a bulk-surface reaction-diffusion model for signalling networks
- The approach of solutions of nonlinear diffusion equations to travelling front solutions
- Turing instabilities in a mathematical model for signaling networks
Cited in
(35)- A bulk-surface mechanobiochemical modelling approach for single cell migration in two-space dimensions
- Cell repolarization: a bifurcation study of spatio-temporal perturbations of polar cells
- Long time behavior and stable patterns in high-dimensional polarity models of asymmetric cell division
- Signaling gradients in surface dynamics as basis for planarian regeneration
- Bulk-surface coupling: derivation of two models
- A moving grid finite element method applied to a mechanobiochemical model for 3D cell migration
- Deterministic and stochastic analysis for different types of regulations in the spontaneous emergence of cell polarity
- A PDE-DDE model for cell polarization in fission yeast
- A parabolic free boundary problem arising in a model of cell polarization
- The linear stability of symmetric spike patterns for a bulk-membrane coupled Gierer-Meinhardt model
- A bulk-surface reaction-diffusion system for cell polarization
- Numerical investigations of the bulk-surface wave pinning model
- Global existence for a bulk/surface model for active-transport-induced polarisation in biological cells
- A cellular Potts energy-based approach to analyse the influence of the surface topography on single cell motility
- Virtual element method for elliptic bulk‐surface PDEs in three space dimensions
- Stochastic Active-Transport Model of Cell Polarization
- Dynamics of shadow system of a singular Gierer-Meinhardt system on an evolving domain
- Phytoplankton competition for nutrients and light in a stratified lake: a mathematical model connecting epilimnion and hypolimnion
- Analysis of spontaneous emergence of cell polarity with delayed negative feedback
- Cell size, mechanical tension, and GTPase signaling in the single cell
- Analysis of bulk-surface reaction-sorption-diffusion systems with Langmuir-type adsorption
- Stability analysis of a bulk-surface reaction model for membrane protein clustering
- Turing patterning in stratified domains
- Generation and Motion of Interfaces in a Mass-Conserving Reaction-Diffusion System
- A Model for Cell Polarization Without Mass Conservation
- A model of cell surface receptor aggregation
- Mathematical modeling of cell polarity establishment of budding yeast
- Cell polarity and movement with reaction-diffusion and moving boundary: rigorous model analysis and robust simulations
- A coupled bulk-surface reaction-diffusion-advection model for cell polarization
- Front propagation in the shadow wave-pinning model
- A conservative finite element ALE scheme for mass-conservative reaction-diffusion equations on evolving two-dimensional domains
- Difference potentials method for models with dynamic boundary conditions and bulk-surface problems
- Pattern Formation Inside Living Cells
- Bulk-surface virtual element method for systems of PDEs in two-space dimensions
- The Bulk-Surface Virtual Element Method for Reaction-Diffusion PDEs: Analysis and Applications
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