A bulk-surface reaction-diffusion system for cell polarization

DOI10.4171/IFB/433zbMATH Open1439.35577arXiv1902.05842MaRDI QIDQ2180656FDOQ2180656

Juan J. Velázquez, Barbara Niethammer, Matthias Röger

Publication date: 14 May 2020

Published in: Interfaces and Free Boundaries (Search for Journal in Brave)

Abstract: We propose a model for cell polarization as a response to an external signal which results in a system of PDEs for different variants of a protein on the cell surface and interior respectively. We study stationary states of this model in certain parameter regimes in which several reaction rates on the membrane as well as the diffusion coefficient within the cell are large. It turns out that in suitable scaling limits steady states converge to solutions of some obstacle type problems. For these limiting problems we prove the onset of polarization if the total mass of protein is sufficiently small. For some variants we can even characterize precisely the critical mass for which polarization occurs.

Full work available at URL: https://arxiv.org/abs/1902.05842

zbMATH Keywords

obstacle problempattern formationpolarizationPDEs on surfaces

Mathematics Subject Classification ID

Pattern formations in context of PDEs (35B36) PDEs in connection with biology, chemistry and other natural sciences (35Q92) PDEs on manifolds (35R01) Free boundary problems for PDEs (35R35) Cell biology (92C37)

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Cited In (9)

• Nontrivial solutions for the Laplace equation with a nonlinear Goldstein-Wentzell boundary condition
• Analysis of bulk-surface reaction-sorption-diffusion systems with Langmuir-type adsorption
• The influence of receptor-mediated interactions on reaction-diffusion mechanisms of cellular self-organisation
• Analysis of a bulk-surface thermistor model for large-area organic LEDs
• Qualitative properties of solutions to a mass-conserving free boundary problem modeling cell polarization
• Generation and Motion of Interfaces in a Mass-Conserving Reaction-Diffusion System
• Numerical investigations of the bulk-surface wave pinning model
• THE USE OF FARADAY INSTABILITY TO PRODUCE DEFINED TOPOLOGICAL ORGANIZATION IN CULTURES OF MAMMALIAN CELLS
• A Parabolic Free Boundary Problem Arising in a Model of Cell Polarization

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