A numerical scheme for a partial differential system motivated by light-triggered drug delivery

DOI10.1016/J.APNUM.2022.09.005MaRDI QIDQ2106209zbMATH OpenOpenAlexFDO

Authors H. P. Gómez, L. Pinto, J. A. Ferreira

Publication date 9 December 2022

Published in Applied Numerical Mathematics (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1016/j.apnum.2022.09.005

zbMATH Keywords

convergence analysisdrug deliveryfinite difference methodNIR light-responsivenonlinear stabilitynumerical simulationsupraconvergence

Mathematics Subject Classification ID

Stability in context of PDEs (35B35) PDEs in connection with biology, chemistry and other natural sciences (35Q92) Finite difference methods for initial value and initial-boundary value problems involving PDEs (65M06) Stability and convergence of numerical methods for initial value and initial-boundary value problems involving PDEs (65M12) Finite difference methods for boundary value problems involving PDEs (65N06) Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45) Medical applications (general) (92C50)

Review text

This article discusses a numerical scheme for nonlinear coupled systems of partial differential equations. The approach combines a finite difference method in space with an implicit-explicit method in time. Furthermore, the convergence of the numerical scheme in both \(H^1\) and \(L^2\) norms are analysed. Numerical experiments are included to support the theoretical findings.

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Cites work

• ADER finite volume schemes for nonlinear reaction-diffusion equations
• Approximating coupled hyperbolic-parabolic systems arising in enhanced drug delivery
• Finite difference methods for a nonlinear and strongly coupled heat and moisture transport system in textile materials
• Implicit-explicit methods for reaction-diffusion problems in pattern formation
• Non-Fickian convection-diffusion models in porous media
• Second order approximations for kinetic and potential energies in Maxwell's wave equations
• Stability of nonlinear convection-diffusion-reaction systems in discontinuous Galerkin methods
• Supraconvergence and supercloseness in Volterra equations
• Supraconvergence of a finite difference scheme for solutions in Hs(0, L)
• Two-grid method for nonlinear reaction-diffusion equations by mixed finite element methods

Cited in

(7)

• Approximating coupled hyperbolic-parabolic systems arising in enhanced drug delivery
• Numerical analysis of a porous-elastic model for convection enhanced drug delivery
• Coupling nonlinear electric fields and temperature to enhance drug transport: an accurate numerical tool
• Convergence of a numerical scheme for a mixed hyperbolic-parabolic system in two space dimensions
• Numerical analysis of light-controlled drug delivery systems
• Numerical simulation and validation of a nonlinear differential system for drug release boosted by light
• Drug release from polymeric platforms for non smooth solutions

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