A generalized moment-based method for estimating parameters of stochastic gene transcription

DOI10.1016/J.MBS.2022.108780zbMATH Open1486.92125OpenAlexW4207079114MaRDI QIDQ2118516FDOQ2118516

Authors: Liang Chen, Chunjuan Zhu, Feng Jiao 

Publication date: 22 March 2022

Published in: Mathematical Biosciences (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1016/j.mbs.2022.108780

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zbMATH Keywords

stochastic gene transcriptionmass functionmaximum-likelihood methodmRNA distributionmoment-based method

Mathematics Subject Classification ID

Genetics and epigenetics (92D10)

Cites Work

• Markovian modelling of gene product synthesis
• Using gene expression noise to understand gene regulation
• The theory of probability. Explorations and applications
• Distribution profiles and their dynamic transition in stochastic gene transcription
• The nonlinear dynamics and fluctuations of mRNA levels in cross-talking pathway activated transcription
• Distribution modes and their corresponding parameter regions in stochastic gene transcription
• Estimation of kinetic parameters of transcription from temporal single-RNA measurements
• Kinetic Foundation of the Zero-Inflated Negative Binomial Model for Single-Cell RNA Sequencing Data

Cited In (6)

• Analytical formula and dynamic profile of mRNA distribution
• Dimensionality reduction via path integration for computing mRNA distributions
• A stochastic model of gene transcription: an application to L1 retrotransposition events
• Estimation of kinetic parameters of transcription from temporal single-RNA measurements
• Distribution modes and their corresponding parameter regions in stochastic gene transcription
• Quantifying heterogeneity of stochastic gene expression

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