A generalized moment-based method for estimating parameters of stochastic gene transcription

DOI10.1016/J.MBS.2022.108780MaRDI QIDQ2118516zbMATHOpenAlexFDO

Authors Liang Chen, Chunjuan Zhu, Feng Jiao

Publication date 22 March 2022

Published in Mathematical Biosciences (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1016/j.mbs.2022.108780

zbMATH Keywords

stochastic gene transcriptionmass functionmaximum-likelihood methodmRNA distributionmoment-based method

Mathematics Subject Classification ID

Genetics and epigenetics (92D10)

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Cites work

• Distribution modes and their corresponding parameter regions in stochastic gene transcription
• Distribution profiles and their dynamic transition in stochastic gene transcription
• Estimation of kinetic parameters of transcription from temporal single-RNA measurements
• Kinetic Foundation of the Zero-Inflated Negative Binomial Model for Single-Cell RNA Sequencing Data
• Markovian modelling of gene product synthesis
• The nonlinear dynamics and fluctuations of mRNA levels in cross-talking pathway activated transcription
• The theory of probability. Explorations and applications
• Using gene expression noise to understand gene regulation

Cited in

(6)

• Distribution modes and their corresponding parameter regions in stochastic gene transcription
• Dimensionality reduction via path integration for computing mRNA distributions
• Estimation of kinetic parameters of transcription from temporal single-RNA measurements
• Quantifying heterogeneity of stochastic gene expression
• Analytical formula and dynamic profile of mRNA distribution
• A stochastic model of gene transcription: an application to L1 retrotransposition events

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