Exact and WKB-approximate distributions in a gene expression model with feedback in burst frequency, burst size, and protein stability

DOI10.3934/DCDSB.2021126zbMATH Open1486.92060OpenAlexW3153586178MaRDI QIDQ2120331FDOQ2120331

Authors: Pavol Bokes 

Publication date: 31 March 2022

Published in: Discrete and Continuous Dynamical Systems. Series B (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.3934/dcdsb.2021126

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zbMATH Keywords

large deviationsfeedbackhybrid modelWKB approximationburstingstochastic gene expressionautoregulationpiecewise-deterministic Markov processHill functiondrift-jump Markov processprotein distributiontranscription delaytranslation delay

Mathematics Subject Classification ID

Biochemistry, molecular biology (92C40) PDEs in connection with biology, chemistry and other natural sciences (35Q92) Feedback control (93B52) Jump processes on general state spaces (60J76)

Cites Work

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Cited In (2)

• Heavy-tailed distributions in a stochastic gene autoregulation model
• Non-monotonicity of Fano factor in a stochastic model for protein expression with sequesterisation at decoy binding sites

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