A DNA-structured mathematical model of cell-cycle progression in cyclic hypoxia

DOI10.1016/J.JTBI.2022.111104MaRDI QIDQ2146758zbMATH OpenOpenAlexWikidataFDO

Authors Giulia L. Celora, Samuel B. Bader, Ester M. Hammond, Joe Pitt-Francis, Philip K. Maini, H. M. Byrne

Publication date 21 June 2022

Published in Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1016/j.jtbi.2022.111104

zbMATH Keywords

model selectioncancermodel calibrationdelay-differential equationcell-cyclecyclic hypoxia

Mathematics Subject Classification ID

PDEs in connection with biology, chemistry and other natural sciences (35Q92) Cell biology (92C37)

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Cites work

• A generalised age- and phase-structured model of human tumour cell populations both unperturbed and exposed to a range of cancer therapies
• A mathematical model for analysis of the cell cycle in cell lines derived from human tumors
• A mathematical model for cell cycle-specific cancer virotherapy
• A mathematical model of cell cycle progression applied to the MCF-7 breast cancer cell line
• A mathematical model of the effects of hypoxia on the cell-cycle of normal and cancer cells
• A nonlinear model of age and size-structured populations with applications to cell cycles
• A nonlinear structured population model of tumor growth with quiescence
• A novel mathematical model of heterogeneous cell proliferation
• AN IN VITRO CELL POPULATION DYNAMICS MODEL INCORPORATING CELL SIZE, QUIESCENCE, AND CONTACT INHIBITION
• An age structured cell cycle model with crowding
• Bayesian calibration, validation and uncertainty quantification for predictive modelling of tumour growth: a tutorial
• Modelling cell death in human tumour cell lines exposed to the anticancer drug paclitaxel
• Modelling the balance between quiescence and cell death in normal and tumour cell populations
• Modelling the flow of cytometric data obtained from unperturbed human tumour cell lines: parameter fitting and comparison
• The steady-states of a multi-compartment, age–size distribution model of cell-growth
• Unraveling the complexity of cell cycle effects of anticancer drugs in cell populations
• Variability in the timing of G\(_{1}\)/S transition

Cited in

(5)

• A mathematical model of the effects of hypoxia on the cell-cycle of normal and cancer cells
• Characterising cancer cell responses to cyclic hypoxia using mathematical modelling
• Mathematical Modelling of the Cell Cycle Stress Response
• Quiescence as a mechanism for cyclical hypoxia and acidosis
• A mathematical model of HiF-\(1{\alpha}\)-mediated response to hypoxia on the G1/S transition

Describes a project that uses

Uses Software

• CMA-ES
• BayesDA
• PINTS

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