A mathematical model of HiF-1-mediated response to hypoxia on the G1/S transition

DOI10.1016/J.MBS.2013.11.007MaRDI QIDQ2452796zbMATH OpenOpenAlexWikidataFDO

Authors B. Bedessem, A. Stéphanou

Publication date 5 June 2014

Published in Mathematical Biosciences (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1016/j.mbs.2013.11.007

zbMATH Keywords

cancercell cycle arrestG1/S transitionHiF-\(1{\alpha}\)hypoxiaquiescence

Mathematics Subject Classification ID

Cell biology (92C37)

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Cites work

• A mathematical model of the effects of hypoxia on the cell-cycle of normal and cancer cells
• A model for restriction point control of the mammalian cell cycle
• Modelling the effects of cell-cycle heterogeneity on the response of a solid tumour to chemotherapy: biological insights from a hybrid multiscale cellular automaton model

Cited in

(14)

• Gene regulation in response to graded hypoxia: the non-redundant roles of the oxygen sensors PHD and FIH in the HIF pathway
• Coarse-graining and hybrid methods for efficient simulation of stochastic multi-scale models of tumour growth
• Towards the design of a patient-specific virtual tumour
• A DNA-structured mathematical model of cell-cycle progression in cyclic hypoxia
• A mathematical model of the effects of hypoxia on the cell-cycle of normal and cancer cells
• Modeling the dynamics of hypoxia inducible factor-1 (HIF-1) within single cells and 3D cell culture systems
• How tumour-induced vascular changes alter angiogenesis: insights from a computational model
• Modeling hypoxia-related inflammation scenarios
• A reduced model of cell metabolism to revisit the glycolysis-OXPHOS relationship in the deregulated tumor microenvironment
• Stochastic multi-scale models of competition within heterogeneous cellular populations: simulation methods and mean-field analysis
• Stochastic multiscale models of cell population dynamics: asymptotic and numerical methods
• Modelling HIF-PHD dynamics and related downstream pathways
• Modelling the impact of HIF on metabolism and the extracellular matrix: consequences for tumour growth and invasion
• From invasion to latency: intracellular noise and cell motility as key controls of the competition between resource-limited cellular populations

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