How drugs modulate the performance of the human heart
DOI10.1101/2021.07.12.452066 10.1007/s00466-022-02146-1; 10.1101/2021.07.12.452066zbMath1494.74055MaRDI QIDQ2150238
Francisco Sahli Costabal, Jiang Yao, Mathias Peirlinck, Ellen Kuhl
Publication date: 27 June 2022
Published in: Computational Mechanics (Search for Journal in Brave)
Full work available at URL: https://doi.org/10.1007/s00466-022-02146-1
cardiac mechanics; cardiac electrophysiology; drug-induced arrhythmia; electro-mechanical whole-heart modeling; hemodynamic coupling
74F10: Fluid-solid interactions (including aero- and hydro-elasticity, porosity, etc.)
74S05: Finite element methods applied to problems in solid mechanics
74F15: Electromagnetic effects in solid mechanics
92C10: Biomechanics
74L15: Biomechanical solid mechanics
76Z05: Physiological flows
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Cites Work
- A generic approach towards finite growth with examples of athlete's heart, cardiac dilation, and cardiac wall thickening
- Associative coupled thermoplasticity at finite strains: Formulation, numerical analysis and implementation
- The living heart project: a robust and integrative simulator for human heart function
- Machine learning in drug development: characterizing the effect of 30 drugs on the QT interval using Gaussian process regression, sensitivity analysis, and uncertainty quantification
- Non-conforming finite-element formulation for cardiac electrophysiology: an effective approach to reduce the computation time of heart simulations without compromising accuracy
- A machine learning method for real-time numerical simulations of cardiac electromechanics
- Sensitivity analysis of a strongly-coupled human-based electromechanical cardiac model: effect of mechanical parameters on physiologically relevant biomarkers
- Multi-fidelity classification using Gaussian processes: accelerating the prediction of large-scale computational models
- The importance of mechano-electrical feedback and inertia in cardiac electromechanics
- A viscoactive constitutive modeling framework with variational updates for the myocardium
- Anatomically accurate high resolution modeling of human whole heart electromechanics: A strongly scalable algebraic multigrid solver method for nonlinear deformation
- Computational modeling of cardiac electrophysiology: A novel finite element approach
- A computational strategy for prestressing patient-specific biomechanical problems under finite deformation
- Mathematical models of the electrical action potential of Purkinje fibre cells
- Constitutive modelling of passive myocardium: a structurally based framework for material characterization
- Computational modeling of electrocardiograms: A finite element approach toward cardiac excitation
