Measurement error correction in particle tracking microrheology

DOI10.1214/21-AOAS1565MaRDI QIDQ2170429zbMATH OpenOpenAlexFDO

Authors Yun Ling, Martin Lysy, Ian Seim, David B. Hill, Jeremy Cribb, M. Gregory Forest, Jay M. Newby

Publication date 5 September 2022

Published in The Annals of Applied Statistics (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1911.06451

zbMATH Keywords

high-frequency filteringmeasurement errorsingle-particle trackingsubdiffusion

Mathematics Subject Classification ID

Time series, auto-correlation, regression, etc. in statistics (GARCH) (62M10) Inference from stochastic processes and prediction (62M20) Applications of statistics to biology and medical sciences; meta analysis (62P10)

Abstract: In diverse biological applications, particle tracking of passive microscopic species has become the experimental measurement of choice -- when either the materials are of limited volume, or so soft as to deform uncontrollably when manipulated by traditional instruments. In a wide range of particle tracking experiments, a ubiquitous finding is that the mean squared displacement (MSD) of particle positions exhibits a power-law signature, the parameters of which reveal valuable information about the viscous and elastic properties of various biomaterials. However, MSD measurements are typically contaminated by complex and interacting sources of instrumental noise. As these often affect the high-frequency bandwidth to which MSD estimates are particularly sensitive, inadequate error correction can lead to severe bias in power law estimation and thereby, the inferred viscoelastic properties. In this article, we propose a novel strategy to filter high-frequency noise from particle tracking measurements. Our filters are shown theoretically to cover a broad spectrum of high-frequency noises, and lead to a parametric estimator of MSD power-law coefficients for which an efficient computational implementation is presented. Based on numerous analyses of experimental and simulated data, results suggest our methods perform very well compared to other denoising procedures.

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Cites work

• An overview of composite likelihood methods
• Displacement ranks of matrices and linear equations
• Fluid heterogeneity detection based on the asymptotic distribution of the time-averaged mean squared displacement in single particle tracking experiments
• Functional data analysis.
• scientific article; zbMATH DE number 3119871 (Why is no real title available?)
• scientific article; zbMATH DE number 3261539 (Why is no real title available?)
• Nonequilibrium statistical mechanics
• Quasi-likelihood and its application. A general approach to optimal parameter estimation
• Stochastic modeling in nanoscale biophysics: subdiffusion within proteins
• Superfast Solution of Real Positive Definite Toeplitz Systems
• The copula information criteria
• THE ESTIMATION AND APPLICATION OF LONG MEMORY TIME SERIES MODELS
• The Fitting of Time-Series Models
• The Focused Information Criterion
• Time series: theory and methods.

Cited in

(2)

• Time-Domain Methods for Diffusive Transport in Soft Matter
• The asymptotic distribution of the pathwise mean squared displacement in single particle tracking experiments

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