Decline in excision circles requires homeostatic renewal or homeostatic death of naive T cells

DOI10.1016/S0022-5193(03)00172-3MaRDI QIDQ2177364zbMATH OpenWikidataFDO

Authors Bas E. Dutilh, Rob J. De Boer

Publication date 6 May 2020

Published in Journal of Theoretical Biology (Search for Journal in Brave)

zbMATH Keywords

homeostasisageingexcision circlesnaive T cellsthymic involution

Mathematics Subject Classification ID

Cell biology (92C37)

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(4)

• Clonal exhaustion as a result of immune deviation
• Quantifying T lymphocyte turnover
• Lifelong dynamics of human CD4\(^+\)CD25\(^+\) regulatory T cells: insights from \textit{in vivo} data and mathematical modeling
• Stochastic niche structure and diversity maintenance in the T cell repertoire

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