A mathematical model of the effects of aging on naive T cell populations and diversity
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Publication:2002143
DOI10.1007/S11538-019-00630-ZzbMATH Open1417.92025arXiv1901.00280OpenAlexW2963222583WikidataQ92763760 ScholiaQ92763760MaRDI QIDQ2002143FDOQ2002143
Authors: Stephanie Lewkiewicz, Tom Chou, Yao-Li Chuang 
Publication date: 11 July 2019
Published in: Bulletin of Mathematical Biology (Search for Journal in Brave)
Abstract: The human adaptive immune response is known to weaken in advanced age, resulting in increased severity of pathogen-born illness, poor vaccine efficacy, and a higher prevalence of cancer in the elderly. Age-related erosion of the T-cell compartment has been implicated as a likely cause, but the underlying mechanisms driving this immunosenescence have not been quantitatively modeled and systematically analyzed. T-cell receptor diversity, or the extent of pathogen-derived antigen responsiveness of the T-cell pool, is known to diminish with age, but inherent experimental difficulties preclude accurate analysis on the full organismal level. In this paper, we formulate a mechanistic mathematical model of T-cell population dynamics on the immunoclonal subpopulation level, which provides quantitative estimates of diversity. We define different estimates for diversity that depend on the individual number of cells in a specific immunoclone. We show that diversity decreases with age primarily due to diminished thymic output of new T-cells and the resulting overall loss of small immunoclones.
Full work available at URL: https://arxiv.org/abs/1901.00280
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Cites Work
- Quantifying T lymphocyte turnover
- The sampling theory of selectively neutral alleles
- Immigration-induced phase transition in a regulated multispecies birth-death process
- How many TCR clonotypes does a body maintain?
- Estimating the Number of Classes via Sample Coverage
- Perturbation theorems for ordinary differential equations
Cited In (5)
- Cell death and the maintenance of immunological memory
- Dynamics of T cell receptor distributions following acute thymic atrophy and resumption
- Mathematical characterization of private and public Immune receptor sequences
- Modeling of T cell population development and estimation of resource allocation effectiveness
- Predicting and explaining with models: a few remarks on mathematical immunology
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