Estimating the health effects of environmental mixtures using Bayesian semiparametric regression and sparsity inducing priors
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Publication:2179967
Abstract: Humans are routinely exposed to mixtures of chemical and other environmental factors, making the quantification of health effects associated with environmental mixtures a critical goal for establishing environmental policy sufficiently protective of human health. The quantification of the effects of exposure to an environmental mixture poses several statistical challenges. It is often the case that exposure to multiple pollutants interact with each other to affect an outcome. Further, the exposure-response relationship between an outcome and some exposures, such as some metals, can exhibit complex, nonlinear forms, since some exposures can be beneficial and detrimental at different ranges of exposure. To estimate the health effects of complex mixtures we propose a flexible Bayesian approach that allows exposures to interact with each other and have nonlinear relationships with the outcome. We induce sparsity using multivariate spike and slab priors to determine which exposures are associated with the outcome, and which exposures interact with each other. The proposed approach is interpretable, as we can use the posterior probabilities of inclusion into the model to identify pollutants that interact with each other. We illustrate our approach's ability to estimate complex functions using simulated data, and apply our method to two studies to determine which environmental pollutants adversely affect health.
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Cites work
- 10.1162/153244303322533223
- A lasso for hierarchical interactions
- A weakly informative default prior distribution for logistic and other regression models
- An introduction to support vector machines and other kernel-based learning methods.
- Asymptotic equivalence of Bayes cross validation and widely applicable information criterion in singular learning theory
- BART: Bayesian additive regression trees
- Bayesian factorizations of big sparse tensors
- Bayesian regression tree models for causal inference: regularization, confounding, and heterogeneous effects (with discussion)
- Bayesian Variable Selection in Linear Regression
- Estimating the health effects of environmental mixtures using Bayesian semiparametric regression and sparsity inducing priors
- scientific article; zbMATH DE number 3583145 (Why is no real title available?)
- scientific article; zbMATH DE number 1911984 (Why is no real title available?)
- scientific article; zbMATH DE number 845714 (Why is no real title available?)
- Low‐Rank Scale‐Invariant Tensor Product Smooths for Generalized Additive Mixed Models
- Model selection for high-dimensional quadratic regression via regularization
- Model Selection in Spline Nonparametric Regression
- Random forests
- Regularization and confounding in linear regression for treatment effect estimation
- Regularization and Variable Selection Via the Elastic Net
- Spike-and-slab priors for function selection in structured additive regression models
- The Adaptive Lasso and Its Oracle Properties
- The composite absolute penalties family for grouped and hierarchical variable selection
- The spike-and-slab LASSO
- Variable Selection and Function Estimation in Additive Nonparametric Regression Using a Data-Based Prior
- Variable selection using adaptive nonlinear interaction structures in high dimensions
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- A Bayesian regression tree approach to identify the effect of nanoparticles' properties on toxicity profiles
- From sources to biomarkers: A hierarchical Bayesian approach for human exposure modeling
- Model-averaged confounder adjustment for estimating multivariate exposure effects with linear regression
- A generalized weighted quantile sum approach for analyzing correlated data in the presence of interactions
- Sparse Bayesian additive nonparametric regression with application to health effects of pesticides mixtures
- Spike-and-Slab Group Lassos for Grouped Regression and Sparse Generalized Additive Models
- A latent functional approach for modeling the effects of multidimensional exposures on disease risk
- Incorporating biological knowledge in analyses of environmental mixtures and health
- Collapsible kernel machine regression for exposomic analyses
- Treatment effect heterogeneity and importance measures for multivariate continuous treatments
- Inferring synergistic and antagonistic interactions in mixtures of exposures
- An interpretable varying coefficients approach to non-linear regression
- Borrowing strength across exposures and outcomes via index models for multi-pollutant mixtures
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