Estimating the health effects of environmental mixtures using Bayesian semiparametric regression and sparsity inducing priors
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Publication:2179967
DOI10.1214/19-AOAS1307zbMATH Open1439.62215arXiv1711.11239OpenAlexW3016515262MaRDI QIDQ2179967FDOQ2179967
Authors: Joseph Antonelli, Maitreyi Mazumdar, David Bellinger, Robert O. Wright, Brent A. Coull, David C. Christiani 
Publication date: 13 May 2020
Published in: The Annals of Applied Statistics (Search for Journal in Brave)
Abstract: Humans are routinely exposed to mixtures of chemical and other environmental factors, making the quantification of health effects associated with environmental mixtures a critical goal for establishing environmental policy sufficiently protective of human health. The quantification of the effects of exposure to an environmental mixture poses several statistical challenges. It is often the case that exposure to multiple pollutants interact with each other to affect an outcome. Further, the exposure-response relationship between an outcome and some exposures, such as some metals, can exhibit complex, nonlinear forms, since some exposures can be beneficial and detrimental at different ranges of exposure. To estimate the health effects of complex mixtures we propose a flexible Bayesian approach that allows exposures to interact with each other and have nonlinear relationships with the outcome. We induce sparsity using multivariate spike and slab priors to determine which exposures are associated with the outcome, and which exposures interact with each other. The proposed approach is interpretable, as we can use the posterior probabilities of inclusion into the model to identify pollutants that interact with each other. We illustrate our approach's ability to estimate complex functions using simulated data, and apply our method to two studies to determine which environmental pollutants adversely affect health.
Full work available at URL: https://arxiv.org/abs/1711.11239
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Nonparametric regression and quantile regression (62G08) Classification and discrimination; cluster analysis (statistical aspects) (62H30) Applications of statistics to biology and medical sciences; meta analysis (62P10) Applications of statistics to environmental and related topics (62P12)
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Cited In (12)
- From sources to biomarkers: A hierarchical Bayesian approach for human exposure modeling
- Kernel machine and distributed lag models for assessing windows of susceptibility to environmental mixtures in children's health studies
- A latent functional approach for modeling the effects of multidimensional exposures on disease risk
- Incorporating biological knowledge in analyses of environmental mixtures and health
- A Bayesian regression tree approach to identify the effect of nanoparticles' properties on toxicity profiles
- Model-averaged confounder adjustment for estimating multivariate exposure effects with linear regression
- Sparse Bayesian additive nonparametric regression with application to health effects of pesticides mixtures
- Spike-and-Slab Group Lassos for Grouped Regression and Sparse Generalized Additive Models
- Integrative statistical methods for exposure mixtures and health
- Estimating the health effects of environmental mixtures using Bayesian semiparametric regression and sparsity inducing priors
- Critical window variable selection for mixtures: estimating the impact of multiple air pollutants on stillbirth
- A generalized weighted quantile sum approach for analyzing correlated data in the presence of interactions
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