Identifying main effects and interactions among exposures using Gaussian processes
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Publication:2078748
Abstract: This article is motivated by the problem of studying the joint effect of different chemical exposures on human health outcomes. This is essentially a nonparametric regression problem, with interest being focused not on a black box for prediction but instead on selection of main effects and interactions. For interpretability, we decompose the expected health outcome into a linear main effect, pairwise interactions, and a non-linear deviation. Our interest is in model selection for these different components, accounting for uncertainty and addressing non-identifability between the linear and nonparametric components of the semiparametric model. We propose a Bayesian approach to inference, placing variable selection priors on the different components, and developing a Markov chain Monte Carlo (MCMC) algorithm. A key component of our approach is the incorporation of a heredity constraint to only include interactions in the presence of main effects, effectively reducing dimensionality of the model search. We adapt a projection approach developed in the spatial statistics literature to enforce identifiability in modeling the nonparametric component using a Gaussian process. We also employ a dimension reduction strategy to sample the non-linear random effects that aids the mixing of the MCMC algorithm. The proposed MixSelect framework is evaluated using a simulation study, and is illustrated using data from the National Health and Nutrition Examination Survey (NHANES). Code is available on GitHub.
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Cites work
- A Computationally Efficient Projection-Based Approach for Spatial Generalized Linear Mixed Models
- A lasso for hierarchical interactions
- Bayesian nonparametric weighted sampling inference
- Bayesian quantile regression
- Bayesian spatial quantile regression
- Bayesian variable selection in quantile regression
- Bayesian variable selection with related predictors
- Deletion/Substitution/Addition Algorithm in Learning with Applications in Genomics
- Efficient Gaussian process regression for large datasets
- scientific article; zbMATH DE number 1034042 (Why is no real title available?)
- scientific article; zbMATH DE number 1077338 (Why is no real title available?)
- Interaction screening for ultrahigh-dimensional data
- Latent factor models for density estimation
- Model selection for high-dimensional quadratic regression via regularization
- Restricted spatial regression in practice: geostatistical models, confounding, and robustness under model misspecification
- Simultaneous probability statements for Bayesian P-splines
- Variable selection for nonparametric Gaussian process priors: Models and computational strategies
Cited in
(11)- Critical window variable selection for mixtures: estimating the impact of multiple air pollutants on stillbirth
- Estimating the health effects of environmental mixtures using Bayesian semiparametric regression and sparsity inducing priors
- Sparse Bayesian additive nonparametric regression with application to health effects of pesticides mixtures
- Bayesian Factor Analysis for Inference on Interactions
- A latent functional approach for modeling the effects of multidimensional exposures on disease risk
- Spike-and-slab least absolute shrinkage and selection operator generalized additive models and scalable algorithms for high-dimensional data analysis
- Collapsible kernel machine regression for exposomic analyses
- Treatment effect heterogeneity and importance measures for multivariate continuous treatments
- Inferring synergistic and antagonistic interactions in mixtures of exposures
- An interpretable varying coefficients approach to non-linear regression
- Borrowing strength across exposures and outcomes via index models for multi-pollutant mixtures
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