A mathematical framework for predicting lifestyles of viral pathogens
From MaRDI portal
Publication:2183171
Abstract: Despite being similar in structure, functioning, and size viral pathogens enjoy very different mostly well-defined ways of life. They occupy their hosts for a few days (influenza), for a few weeks (measles), or even lifelong (HCV), which manifests in acute or chronic infections. The various transmission routes (airborne, via direct contact, etc.), degrees of infectiousness (referring to the load required for transmission), antigenic variation/immune escape and virulence define further pathogenic lifestyles. To survive pathogens must infect new hosts; the success determines their fitness. Infection happens with a certain likelihood during contact of hosts, where contact can also be mediated by vectors. Besides structural aspects of the host-contact network, three parameters/concepts appear to be key: the contact rate and the infectiousness during contact, which encode the mode of transmission, and third the immunity of susceptible hosts. From here, what can be concluded about the evolutionary strategies of viral pathogens? This is the biological question addressed in this paper. The answer extends earlier results (Lange & Ferguson 2009, PLoS Comput Biol 5 (10): e1000536) and makes explicit connection to another basic work on the evolution of pathogens (Grenfell et al. 2004, Science 303: 327-332). A mathematical framework is presented that models intra- and inter-host dynamics in a minimalistic but unified fashion covering a broad spectrum of viral pathogens, including those that cause flu-like infections, childhood diseases, and sexually transmitted infections. These pathogens turn out as local maxima of the fitness landscape. The models involve differential- and integral equations, agent-based simulation, networks, and probability.
Recommendations
- Computational methods for multiscale modelling of virus infection dynamics
- Modelling stochastic and deterministic behaviours in virus infection dynamics
- Mathematical virology: a novel approach to the structure and assembly of viruses
- A mathematical modeling and dynamical features in the spreading of virus infectious diseases
- A dynamic model of virus infections
- Stochastic modeling and simulation of viral evolution
- Basic stochastic models for viral infection within a host
- Global properties of basic virus dynamics models
- The effects of distributed life cycles on the dynamics of viral infections
Cites work
- Adaptive Dynamics of Infectious Diseases
- Evaluating the importance of within- and between-host selection pressures on the evolution of chronic pathogens
- Heterogeneous viral strategies promote coexistence in virus-microbe systems
- Modeling inoculum dose dependent patterns of acute virus infections
- Necessary and sufficient conditions for the existence of an optimisation principle in evolution
- On the definition and the computation of the basic reproduction ratio \(R_ 0\) in models for infectious diseases in heterogeneous populations
- Reconstruction of disease transmission rates: applications to measles, dengue, and influenza
- The failure of \(R_{0}\)
- The logic of animal conflict
- Towards multiscale modeling of influenza infection
- When does pathogen evolution maximize the basic reproductive number in well-mixed host-pathogen systems?
This page was built for publication: A mathematical framework for predicting lifestyles of viral pathogens
Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q2183171)
